6JII

Structure of RyR2 (F/A/C/L-Ca2+/apo-CaM-M dataset)

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J	Peptidyl-prolyl cis-trans isomerase FKBP1B	polymer	108	11798.5	4	UniProt (P68106) Pfam (PF00254) In PDB	Homo sapiens (Human)	PPIase FKBP1B,12.6 kDa FK506-binding protein,FKBP-12.6,FK506-binding protein 1B,FKBP-1B,Immunophilin FKBP12.6,Rotamase,h-FKBP-12
2	B, E, H, K	Ryr2	polymer	4968	564905.6	4		Sus scrofa
3	C, F, I, L	Calmodulin-1	polymer	149	16620.4	4	UniProt (P0DP23) Pfam (PF13499) In PDB	Homo sapiens (Human)
4	B, E, H, K	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
5	B, E, H, K	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
6	K, B, E, H	CAFFEINE	non-polymer		194.2	4	Chemie (CFF)
7	K, B, E, H	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	4	Chemie (ATP)

Sequence modifications

C, F, I, L: 1 - 149 (UniProt: P0DP23)

PDB	External Database	Details
Ala 32	Glu 32	engineered mutation
Ala 68	Glu 68	engineered mutation
Ala 105	Glu 105	engineered mutation
Ala 141	Glu 141	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	2373298.1
Non-Polymers*	Number of molecules	16
	Total formula weight	3227.4
All*	Total formula weight	2376525.5

*Water molecules are not included.