Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6JII

Structure of RyR2 (F/A/C/L-Ca2+/apo-CaM-M dataset)

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000413biological_processprotein peptidyl-prolyl isomerization
A0002027biological_processregulation of heart rate
A0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
A0005102molecular_functionsignaling receptor binding
A0005219molecular_functionryanodine-sensitive calcium-release channel activity
A0005515molecular_functionprotein binding
A0005528molecular_functionFK506 binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006458biological_process'de novo' protein folding
A0006939biological_processsmooth muscle contraction
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0009749biological_processresponse to glucose
A0010033biological_processresponse to organic substance
A0010459biological_processnegative regulation of heart rate
A0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A0016020cellular_componentmembrane
A0016529cellular_componentsarcoplasmic reticulum
A0016853molecular_functionisomerase activity
A0019227biological_processneuronal action potential propagation
A0019855molecular_functioncalcium channel inhibitor activity
A0022417biological_processprotein maturation by protein folding
A0030018cellular_componentZ disc
A0030073biological_processinsulin secretion
A0030551molecular_functioncyclic nucleotide binding
A0032515biological_processnegative regulation of phosphoprotein phosphatase activity
A0033017cellular_componentsarcoplasmic reticulum membrane
A0033197biological_processresponse to vitamin E
A0034704cellular_componentcalcium channel complex
A0035584biological_processcalcium-mediated signaling using intracellular calcium source
A0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
A0042026biological_processprotein refolding
A0042098biological_processT cell proliferation
A0042542biological_processresponse to hydrogen peroxide
A0044325molecular_functiontransmembrane transporter binding
A0048680biological_processpositive regulation of axon regeneration
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
A0051284biological_processpositive regulation of sequestering of calcium ion
A0051480biological_processregulation of cytosolic calcium ion concentration
A0051775biological_processresponse to redox state
A0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
A0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
A0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
A0086064biological_processcell communication by electrical coupling involved in cardiac conduction
B0005216molecular_functionmonoatomic ion channel activity
B0005219molecular_functionryanodine-sensitive calcium-release channel activity
B0005262molecular_functioncalcium channel activity
B0005509molecular_functioncalcium ion binding
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0016020cellular_componentmembrane
B0055085biological_processtransmembrane transport
B0070588biological_processcalcium ion transmembrane transport
C0000086biological_processG2/M transition of mitotic cell cycle
C0000922cellular_componentspindle pole
C0002027biological_processregulation of heart rate
C0005509molecular_functioncalcium ion binding
C0005513biological_processdetection of calcium ion
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005813cellular_componentcentrosome
C0005819cellular_componentspindle
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005876cellular_componentspindle microtubule
C0005886cellular_componentplasma membrane
C0005929cellular_componentcilium
C0007186biological_processG protein-coupled receptor signaling pathway
C0008076cellular_componentvoltage-gated potassium channel complex
C0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
C0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
C0010856molecular_functionadenylate cyclase activator activity
C0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C0016020cellular_componentmembrane
C0016240biological_processautophagosome membrane docking
C0019855molecular_functioncalcium channel inhibitor activity
C0019901molecular_functionprotein kinase binding
C0021762biological_processsubstantia nigra development
C0030017cellular_componentsarcomere
C0030234molecular_functionenzyme regulator activity
C0031432molecular_functiontitin binding
C0031514cellular_componentmotile cilium
C0031954biological_processpositive regulation of protein autophosphorylation
C0031982cellular_componentvesicle
C0032465biological_processregulation of cytokinesis
C0032516biological_processpositive regulation of phosphoprotein phosphatase activity
C0032991cellular_componentprotein-containing complex
C0034704cellular_componentcalcium channel complex
C0035307biological_processpositive regulation of protein dephosphorylation
C0035458biological_processcellular response to interferon-beta
C0042995cellular_componentcell projection
C0043209cellular_componentmyelin sheath
C0043539molecular_functionprotein serine/threonine kinase activator activity
C0044325molecular_functiontransmembrane transporter binding
C0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
C0046872molecular_functionmetal ion binding
C0048306molecular_functioncalcium-dependent protein binding
C0050848biological_processregulation of calcium-mediated signaling
C0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
C0051592biological_processresponse to calcium ion
C0055117biological_processregulation of cardiac muscle contraction
C0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
C0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
C0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
C0071346biological_processcellular response to type II interferon
C0071902biological_processpositive regulation of protein serine/threonine kinase activity
C0072542molecular_functionprotein phosphatase activator activity
C0097225cellular_componentsperm midpiece
C0098901biological_processregulation of cardiac muscle cell action potential
C0140056biological_processorganelle localization by membrane tethering
C1901842biological_processnegative regulation of high voltage-gated calcium channel activity
C1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
C1902494cellular_componentcatalytic complex
C1905913biological_processnegative regulation of calcium ion export across plasma membrane
C1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
D0000413biological_processprotein peptidyl-prolyl isomerization
D0002027biological_processregulation of heart rate
D0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
D0005102molecular_functionsignaling receptor binding
D0005219molecular_functionryanodine-sensitive calcium-release channel activity
D0005515molecular_functionprotein binding
D0005528molecular_functionFK506 binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006458biological_process'de novo' protein folding
D0006939biological_processsmooth muscle contraction
D0007204biological_processpositive regulation of cytosolic calcium ion concentration
D0009749biological_processresponse to glucose
D0010033biological_processresponse to organic substance
D0010459biological_processnegative regulation of heart rate
D0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D0016020cellular_componentmembrane
D0016529cellular_componentsarcoplasmic reticulum
D0016853molecular_functionisomerase activity
D0019227biological_processneuronal action potential propagation
D0019855molecular_functioncalcium channel inhibitor activity
D0022417biological_processprotein maturation by protein folding
D0030018cellular_componentZ disc
D0030073biological_processinsulin secretion
D0030551molecular_functioncyclic nucleotide binding
D0032515biological_processnegative regulation of phosphoprotein phosphatase activity
D0033017cellular_componentsarcoplasmic reticulum membrane
D0033197biological_processresponse to vitamin E
D0034704cellular_componentcalcium channel complex
D0035584biological_processcalcium-mediated signaling using intracellular calcium source
D0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
D0042026biological_processprotein refolding
D0042098biological_processT cell proliferation
D0042542biological_processresponse to hydrogen peroxide
D0044325molecular_functiontransmembrane transporter binding
D0048680biological_processpositive regulation of axon regeneration
D0051209biological_processrelease of sequestered calcium ion into cytosol
D0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
D0051284biological_processpositive regulation of sequestering of calcium ion
D0051480biological_processregulation of cytosolic calcium ion concentration
D0051775biological_processresponse to redox state
D0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
D0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
D0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
D0086064biological_processcell communication by electrical coupling involved in cardiac conduction
E0005216molecular_functionmonoatomic ion channel activity
E0005219molecular_functionryanodine-sensitive calcium-release channel activity
E0005262molecular_functioncalcium channel activity
E0005509molecular_functioncalcium ion binding
E0006811biological_processmonoatomic ion transport
E0006816biological_processcalcium ion transport
E0006874biological_processintracellular calcium ion homeostasis
E0016020cellular_componentmembrane
E0055085biological_processtransmembrane transport
E0070588biological_processcalcium ion transmembrane transport
F0000086biological_processG2/M transition of mitotic cell cycle
F0000922cellular_componentspindle pole
F0002027biological_processregulation of heart rate
F0005509molecular_functioncalcium ion binding
F0005513biological_processdetection of calcium ion
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005813cellular_componentcentrosome
F0005819cellular_componentspindle
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005876cellular_componentspindle microtubule
F0005886cellular_componentplasma membrane
F0005929cellular_componentcilium
F0007186biological_processG protein-coupled receptor signaling pathway
F0008076cellular_componentvoltage-gated potassium channel complex
F0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
F0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
F0010856molecular_functionadenylate cyclase activator activity
F0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F0016020cellular_componentmembrane
F0016240biological_processautophagosome membrane docking
F0019855molecular_functioncalcium channel inhibitor activity
F0019901molecular_functionprotein kinase binding
F0021762biological_processsubstantia nigra development
F0030017cellular_componentsarcomere
F0030234molecular_functionenzyme regulator activity
F0031432molecular_functiontitin binding
F0031514cellular_componentmotile cilium
F0031954biological_processpositive regulation of protein autophosphorylation
F0031982cellular_componentvesicle
F0032465biological_processregulation of cytokinesis
F0032516biological_processpositive regulation of phosphoprotein phosphatase activity
F0032991cellular_componentprotein-containing complex
F0034704cellular_componentcalcium channel complex
F0035307biological_processpositive regulation of protein dephosphorylation
F0035458biological_processcellular response to interferon-beta
F0042995cellular_componentcell projection
F0043209cellular_componentmyelin sheath
F0043539molecular_functionprotein serine/threonine kinase activator activity
F0044325molecular_functiontransmembrane transporter binding
F0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
F0046872molecular_functionmetal ion binding
F0048306molecular_functioncalcium-dependent protein binding
F0050848biological_processregulation of calcium-mediated signaling
F0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
F0051592biological_processresponse to calcium ion
F0055117biological_processregulation of cardiac muscle contraction
F0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
F0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
F0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
F0071346biological_processcellular response to type II interferon
F0071902biological_processpositive regulation of protein serine/threonine kinase activity
F0072542molecular_functionprotein phosphatase activator activity
F0097225cellular_componentsperm midpiece
F0098901biological_processregulation of cardiac muscle cell action potential
F0140056biological_processorganelle localization by membrane tethering
F1901842biological_processnegative regulation of high voltage-gated calcium channel activity
F1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
F1902494cellular_componentcatalytic complex
F1905913biological_processnegative regulation of calcium ion export across plasma membrane
F1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
G0000413biological_processprotein peptidyl-prolyl isomerization
G0002027biological_processregulation of heart rate
G0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
G0005102molecular_functionsignaling receptor binding
G0005219molecular_functionryanodine-sensitive calcium-release channel activity
G0005515molecular_functionprotein binding
G0005528molecular_functionFK506 binding
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0006458biological_process'de novo' protein folding
G0006939biological_processsmooth muscle contraction
G0007204biological_processpositive regulation of cytosolic calcium ion concentration
G0009749biological_processresponse to glucose
G0010033biological_processresponse to organic substance
G0010459biological_processnegative regulation of heart rate
G0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
G0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
G0016020cellular_componentmembrane
G0016529cellular_componentsarcoplasmic reticulum
G0016853molecular_functionisomerase activity
G0019227biological_processneuronal action potential propagation
G0019855molecular_functioncalcium channel inhibitor activity
G0022417biological_processprotein maturation by protein folding
G0030018cellular_componentZ disc
G0030073biological_processinsulin secretion
G0030551molecular_functioncyclic nucleotide binding
G0032515biological_processnegative regulation of phosphoprotein phosphatase activity
G0033017cellular_componentsarcoplasmic reticulum membrane
G0033197biological_processresponse to vitamin E
G0034704cellular_componentcalcium channel complex
G0035584biological_processcalcium-mediated signaling using intracellular calcium source
G0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
G0042026biological_processprotein refolding
G0042098biological_processT cell proliferation
G0042542biological_processresponse to hydrogen peroxide
G0044325molecular_functiontransmembrane transporter binding
G0048680biological_processpositive regulation of axon regeneration
G0051209biological_processrelease of sequestered calcium ion into cytosol
G0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
G0051284biological_processpositive regulation of sequestering of calcium ion
G0051480biological_processregulation of cytosolic calcium ion concentration
G0051775biological_processresponse to redox state
G0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
G0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
G0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
G0086064biological_processcell communication by electrical coupling involved in cardiac conduction
H0005216molecular_functionmonoatomic ion channel activity
H0005219molecular_functionryanodine-sensitive calcium-release channel activity
H0005262molecular_functioncalcium channel activity
H0005509molecular_functioncalcium ion binding
H0006811biological_processmonoatomic ion transport
H0006816biological_processcalcium ion transport
H0006874biological_processintracellular calcium ion homeostasis
H0016020cellular_componentmembrane
H0055085biological_processtransmembrane transport
H0070588biological_processcalcium ion transmembrane transport
I0000086biological_processG2/M transition of mitotic cell cycle
I0000922cellular_componentspindle pole
I0002027biological_processregulation of heart rate
I0005509molecular_functioncalcium ion binding
I0005513biological_processdetection of calcium ion
I0005515molecular_functionprotein binding
I0005576cellular_componentextracellular region
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005737cellular_componentcytoplasm
I0005813cellular_componentcentrosome
I0005819cellular_componentspindle
I0005829cellular_componentcytosol
I0005856cellular_componentcytoskeleton
I0005876cellular_componentspindle microtubule
I0005886cellular_componentplasma membrane
I0005929cellular_componentcilium
I0007186biological_processG protein-coupled receptor signaling pathway
I0008076cellular_componentvoltage-gated potassium channel complex
I0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
I0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
I0010856molecular_functionadenylate cyclase activator activity
I0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
I0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
I0016020cellular_componentmembrane
I0016240biological_processautophagosome membrane docking
I0019855molecular_functioncalcium channel inhibitor activity
I0019901molecular_functionprotein kinase binding
I0021762biological_processsubstantia nigra development
I0030017cellular_componentsarcomere
I0030234molecular_functionenzyme regulator activity
I0031432molecular_functiontitin binding
I0031514cellular_componentmotile cilium
I0031954biological_processpositive regulation of protein autophosphorylation
I0031982cellular_componentvesicle
I0032465biological_processregulation of cytokinesis
I0032516biological_processpositive regulation of phosphoprotein phosphatase activity
I0032991cellular_componentprotein-containing complex
I0034704cellular_componentcalcium channel complex
I0035307biological_processpositive regulation of protein dephosphorylation
I0035458biological_processcellular response to interferon-beta
I0042995cellular_componentcell projection
I0043209cellular_componentmyelin sheath
I0043539molecular_functionprotein serine/threonine kinase activator activity
I0044325molecular_functiontransmembrane transporter binding
I0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
I0046872molecular_functionmetal ion binding
I0048306molecular_functioncalcium-dependent protein binding
I0050848biological_processregulation of calcium-mediated signaling
I0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
I0051592biological_processresponse to calcium ion
I0055117biological_processregulation of cardiac muscle contraction
I0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
I0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
I0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
I0071346biological_processcellular response to type II interferon
I0071902biological_processpositive regulation of protein serine/threonine kinase activity
I0072542molecular_functionprotein phosphatase activator activity
I0097225cellular_componentsperm midpiece
I0098901biological_processregulation of cardiac muscle cell action potential
I0140056biological_processorganelle localization by membrane tethering
I1901842biological_processnegative regulation of high voltage-gated calcium channel activity
I1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
I1902494cellular_componentcatalytic complex
I1905913biological_processnegative regulation of calcium ion export across plasma membrane
I1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
J0000413biological_processprotein peptidyl-prolyl isomerization
J0002027biological_processregulation of heart rate
J0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
J0005102molecular_functionsignaling receptor binding
J0005219molecular_functionryanodine-sensitive calcium-release channel activity
J0005515molecular_functionprotein binding
J0005528molecular_functionFK506 binding
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0006458biological_process'de novo' protein folding
J0006939biological_processsmooth muscle contraction
J0007204biological_processpositive regulation of cytosolic calcium ion concentration
J0009749biological_processresponse to glucose
J0010033biological_processresponse to organic substance
J0010459biological_processnegative regulation of heart rate
J0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
J0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
J0016020cellular_componentmembrane
J0016529cellular_componentsarcoplasmic reticulum
J0016853molecular_functionisomerase activity
J0019227biological_processneuronal action potential propagation
J0019855molecular_functioncalcium channel inhibitor activity
J0022417biological_processprotein maturation by protein folding
J0030018cellular_componentZ disc
J0030073biological_processinsulin secretion
J0030551molecular_functioncyclic nucleotide binding
J0032515biological_processnegative regulation of phosphoprotein phosphatase activity
J0033017cellular_componentsarcoplasmic reticulum membrane
J0033197biological_processresponse to vitamin E
J0034704cellular_componentcalcium channel complex
J0035584biological_processcalcium-mediated signaling using intracellular calcium source
J0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
J0042026biological_processprotein refolding
J0042098biological_processT cell proliferation
J0042542biological_processresponse to hydrogen peroxide
J0044325molecular_functiontransmembrane transporter binding
J0048680biological_processpositive regulation of axon regeneration
J0051209biological_processrelease of sequestered calcium ion into cytosol
J0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
J0051284biological_processpositive regulation of sequestering of calcium ion
J0051480biological_processregulation of cytosolic calcium ion concentration
J0051775biological_processresponse to redox state
J0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
J0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
J0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
J0086064biological_processcell communication by electrical coupling involved in cardiac conduction
K0005216molecular_functionmonoatomic ion channel activity
K0005219molecular_functionryanodine-sensitive calcium-release channel activity
K0005262molecular_functioncalcium channel activity
K0005509molecular_functioncalcium ion binding
K0006811biological_processmonoatomic ion transport
K0006816biological_processcalcium ion transport
K0006874biological_processintracellular calcium ion homeostasis
K0016020cellular_componentmembrane
K0055085biological_processtransmembrane transport
K0070588biological_processcalcium ion transmembrane transport
L0000086biological_processG2/M transition of mitotic cell cycle
L0000922cellular_componentspindle pole
L0002027biological_processregulation of heart rate
L0005509molecular_functioncalcium ion binding
L0005513biological_processdetection of calcium ion
L0005515molecular_functionprotein binding
L0005576cellular_componentextracellular region
L0005634cellular_componentnucleus
L0005654cellular_componentnucleoplasm
L0005737cellular_componentcytoplasm
L0005813cellular_componentcentrosome
L0005819cellular_componentspindle
L0005829cellular_componentcytosol
L0005856cellular_componentcytoskeleton
L0005876cellular_componentspindle microtubule
L0005886cellular_componentplasma membrane
L0005929cellular_componentcilium
L0007186biological_processG protein-coupled receptor signaling pathway
L0008076cellular_componentvoltage-gated potassium channel complex
L0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
L0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
L0010856molecular_functionadenylate cyclase activator activity
L0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
L0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
L0016020cellular_componentmembrane
L0016240biological_processautophagosome membrane docking
L0019855molecular_functioncalcium channel inhibitor activity
L0019901molecular_functionprotein kinase binding
L0021762biological_processsubstantia nigra development
L0030017cellular_componentsarcomere
L0030234molecular_functionenzyme regulator activity
L0031432molecular_functiontitin binding
L0031514cellular_componentmotile cilium
L0031954biological_processpositive regulation of protein autophosphorylation
L0031982cellular_componentvesicle
L0032465biological_processregulation of cytokinesis
L0032516biological_processpositive regulation of phosphoprotein phosphatase activity
L0032991cellular_componentprotein-containing complex
L0034704cellular_componentcalcium channel complex
L0035307biological_processpositive regulation of protein dephosphorylation
L0035458biological_processcellular response to interferon-beta
L0042995cellular_componentcell projection
L0043209cellular_componentmyelin sheath
L0043539molecular_functionprotein serine/threonine kinase activator activity
L0044325molecular_functiontransmembrane transporter binding
L0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
L0046872molecular_functionmetal ion binding
L0048306molecular_functioncalcium-dependent protein binding
L0050848biological_processregulation of calcium-mediated signaling
L0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
L0051592biological_processresponse to calcium ion
L0055117biological_processregulation of cardiac muscle contraction
L0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
L0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
L0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
L0071346biological_processcellular response to type II interferon
L0071902biological_processpositive regulation of protein serine/threonine kinase activity
L0072542molecular_functionprotein phosphatase activator activity
L0097225cellular_componentsperm midpiece
L0098901biological_processregulation of cardiac muscle cell action potential
L0140056biological_processorganelle localization by membrane tethering
L1901842biological_processnegative regulation of high voltage-gated calcium channel activity
L1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
L1902494cellular_componentcatalytic complex
L1905913biological_processnegative regulation of calcium ion export across plasma membrane
L1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN B 6000
ChainResidue
BCYS4889
BILE4891
BCYS4892
BHIS4914

site_idAC2
Number of Residues3
Detailsbinding site for residue CA B 6001
ChainResidue
BGLU3923
BGLN3926
BTHR4932

site_idAC3
Number of Residues3
Detailsbinding site for residue CFF B 6002
ChainResidue
BTYR4945
BTRP4646
BILE4927

site_idAC4
Number of Residues8
Detailsbinding site for residue ATP B 6003
ChainResidue
BLYS4167
BLYS4170
BMET4885
BLYS4888
BCYS4889
BPHE4890
BILE4891
BTHR4910

site_idAC5
Number of Residues4
Detailsbinding site for residue ZN E 6000
ChainResidue
ECYS4889
EILE4891
ECYS4892
EHIS4914

site_idAC6
Number of Residues3
Detailsbinding site for residue CA E 6001
ChainResidue
EGLU3923
EGLN3926
ETHR4932

site_idAC7
Number of Residues3
Detailsbinding site for residue CFF E 6002
ChainResidue
ETRP4646
EILE4927
ETYR4945

site_idAC8
Number of Residues9
Detailsbinding site for residue ATP E 6003
ChainResidue
ELYS4167
ELYS4170
EARG4171
EMET4885
ELYS4888
ECYS4889
EPHE4890
EILE4891
ETHR4910

site_idAC9
Number of Residues4
Detailsbinding site for residue ZN H 6000
ChainResidue
HCYS4889
HILE4891
HCYS4892
HHIS4914

site_idAD1
Number of Residues3
Detailsbinding site for residue CA H 6001
ChainResidue
HGLU3923
HGLN3926
HTHR4932

site_idAD2
Number of Residues3
Detailsbinding site for residue CFF H 6002
ChainResidue
HTRP4646
HILE4927
HTYR4945

site_idAD3
Number of Residues9
Detailsbinding site for residue ATP H 6003
ChainResidue
HLYS4167
HLYS4170
HARG4171
HMET4885
HLYS4888
HCYS4889
HPHE4890
HILE4891
HTHR4910

site_idAD4
Number of Residues4
Detailsbinding site for residue ZN K 6000
ChainResidue
KCYS4889
KILE4891
KCYS4892
KHIS4914

site_idAD5
Number of Residues3
Detailsbinding site for residue CA K 6001
ChainResidue
KGLU3923
KGLN3926
KTHR4932

site_idAD6
Number of Residues3
Detailsbinding site for residue CFF K 6002
ChainResidue
KTRP4646
KILE4927
KTYR4945

site_idAD7
Number of Residues9
Detailsbinding site for residue ATP K 6003
ChainResidue
KLYS4167
KLYS4170
KARG4171
KMET4885
KLYS4888
KCYS4889
KPHE4890
KILE4891
KTHR4910

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues40
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:4UMO, ECO:0007744|PDB:4V0C, ECO:0007744|PDB:5J03
ChainResidueDetails
CASP21
CALA68
FASP21
FASP23
FASP25
FTHR27
FALA32
FASP57
FASP59
FASN61
FTHR63
CASP23
FALA68
IASP21
IASP23
IASP25
ITHR27
IALA32
IASP57
IASP59
IASN61
ITHR63
CASP25
IALA68
LASP21
LASP23
LASP25
LTHR27
LALA32
LASP57
LASP59
LASN61
LTHR63
CTHR27
LALA68
CALA32
CASP57
CASP59
CASN61
CTHR63

site_idSWS_FT_FI2
Number of Residues40
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03
ChainResidueDetails
CASP94
CALA141
FASP94
FASP96
FASN98
FTYR100
FALA105
FASP130
FASP132
FASP134
FGLN136
CASP96
FALA141
IASP94
IASP96
IASN98
ITYR100
IALA105
IASP130
IASP132
IASP134
IGLN136
CASN98
IALA141
LASP94
LASP96
LASN98
LTYR100
LALA105
LASP130
LASP132
LASP134
LGLN136
CTYR100
LALA141
CALA105
CASP130
CASP132
CASP134
CGLN136

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:7093203, ECO:0000269|Ref.7, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712
ChainResidueDetails
CALA2
FALA2
IALA2
LALA2

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
CLYS22
FLYS22
ILYS22
LLYS22

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphothreonine; by CaMK4 => ECO:0000250|UniProtKB:P0DP29
ChainResidueDetails
CTHR45
FTHR45
ITHR45
LTHR45

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER82
FSER82
ISER82
LSER82

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
CLYS95
FLYS95
ILYS95
LLYS95

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332
ChainResidueDetails
CTYR100
FTYR100
ITYR100
LTYR100

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
CSER102
FSER102
ISER102
LSER102

site_idSWS_FT_FI10
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
CTHR111
FTHR111
ITHR111
LTHR111

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0007744|PubMed:24129315
ChainResidueDetails
CLYS116
FLYS116
ILYS116
LLYS116

site_idSWS_FT_FI12
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332
ChainResidueDetails
CTYR139
FTYR139
ITYR139
LTYR139

site_idSWS_FT_FI13
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157
ChainResidueDetails
CLYS22
FLYS22
ILYS22
LLYS22

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon