6JBJ

Cryo-EM structure of human lysosomal cobalamin exporter ABCD4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	ATP-binding cassette sub-family D member 4	polymer	648	73123.7	2	UniProt (O14678) Pfam (PF06472) Pfam (PF00005) In PDB	Homo sapiens (Human)	PMP70-related protein,P70R,Peroxisomal membrane protein 1-like,PXMP1-L,Peroxisomal membrane protein 69,PMP69
2	A, B	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	2	Chemie (ATP)

Sequence modifications

A, B: 2 - 606 (UniProt: O14678)

PDB	External Database	Details
Met -41	-	expression tag
Ala -40	-	expression tag
Ser -39	-	expression tag
Trp -38	-	expression tag
Ser -37	-	expression tag
His -36	-	expression tag
Pro -35	-	expression tag
Gln -34	-	expression tag
Phe -33	-	expression tag
Glu -32	-	expression tag
Lys -31	-	expression tag
Gly -30	-	expression tag
Gly -29	-	expression tag
Gly -28	-	expression tag
Ala -27	-	expression tag
Arg -26	-	expression tag
Gly -25	-	expression tag
Gly -24	-	expression tag
Ser -23	-	expression tag
Gly -22	-	expression tag
Gly -21	-	expression tag
Gly -20	-	expression tag
Ser -19	-	expression tag
Trp -18	-	expression tag
Ser -17	-	expression tag
His -16	-	expression tag
Pro -15	-	expression tag
Gln -14	-	expression tag
Phe -13	-	expression tag
Glu -12	-	expression tag
Lys -11	-	expression tag
Gly -10	-	expression tag
Phe -9	-	expression tag
Asp -8	-	expression tag
Tyr -7	-	expression tag
Lys -6	-	expression tag
Asp -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Lys -1	-	expression tag
Gly 0	-	expression tag
Thr 1	-	expression tag
Gln 549	Glu 549	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	146247.4
Non-Polymers*	Number of molecules	2
	Total formula weight	1014.4
All*	Total formula weight	147261.8

*Water molecules are not included.