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6JBJ

Cryo-EM structure of human lysosomal cobalamin exporter ABCD4

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0005324molecular_functionlong-chain fatty acid transmembrane transporter activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005777cellular_componentperoxisome
A0005778cellular_componentperoxisomal membrane
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0006635biological_processfatty acid beta-oxidation
A0007031biological_processperoxisome organization
A0009235biological_processcobalamin metabolic process
A0015420molecular_functionABC-type vitamin B12 transporter activity
A0015889biological_processcobalamin transport
A0015910biological_processlong-chain fatty acid import into peroxisome
A0016020cellular_componentmembrane
A0016887molecular_functionATP hydrolysis activity
A0042626molecular_functionATPase-coupled transmembrane transporter activity
A0042760biological_processvery long-chain fatty acid catabolic process
A0042802molecular_functionidentical protein binding
A0043190cellular_componentATP-binding cassette (ABC) transporter complex
A0055085biological_processtransmembrane transport
A0140359molecular_functionABC-type transporter activity
A1990830biological_processcellular response to leukemia inhibitory factor
B0000166molecular_functionnucleotide binding
B0005324molecular_functionlong-chain fatty acid transmembrane transporter activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005777cellular_componentperoxisome
B0005778cellular_componentperoxisomal membrane
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0006635biological_processfatty acid beta-oxidation
B0007031biological_processperoxisome organization
B0009235biological_processcobalamin metabolic process
B0015420molecular_functionABC-type vitamin B12 transporter activity
B0015889biological_processcobalamin transport
B0015910biological_processlong-chain fatty acid import into peroxisome
B0016020cellular_componentmembrane
B0016887molecular_functionATP hydrolysis activity
B0042626molecular_functionATPase-coupled transmembrane transporter activity
B0042760biological_processvery long-chain fatty acid catabolic process
B0042802molecular_functionidentical protein binding
B0043190cellular_componentATP-binding cassette (ABC) transporter complex
B0055085biological_processtransmembrane transport
B0140359molecular_functionABC-type transporter activity
B1990830biological_processcellular response to leukemia inhibitory factor
Functional Information from PDB Data
site_idAC1
Number of Residues18
Detailsbinding site for residue ATP A 701
ChainResidue
AALA396
ATRP438
AGLN461
BARG508
BASP522
BVAL523
BSER525
BPRO526
BGLY527
BGLU528
ATHR423
AGLY424
ATHR425
AGLY426
ALYS427
ATHR428
ASER429
AARG432

site_idAC2
Number of Residues18
Detailsbinding site for residue ATP B 701
ChainResidue
AARG508
AASP522
AVAL523
ASER525
APRO526
AGLY527
AGLU528
BALA396
BTHR423
BGLY424
BTHR425
BGLY426
BLYS427
BTHR428
BSER429
BARG432
BTRP438
BGLN461

Functional Information from PROSITE/UniProt
site_idPS00211
Number of Residues15
DetailsABC_TRANSPORTER_1 ABC transporters family signature. LSPGEMQRLSFARLF
ChainResidueDetails
ALEU524-PHE538

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues200
DetailsTRANSMEM: Helical => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
APHE43-ILE63
BALA314-LEU334
ALEU76-LEU96
AILE190-MET210
ATYR279-GLY299
AALA314-LEU334
BPHE43-ILE63
BLEU76-LEU96
BILE190-MET210
BTYR279-GLY299

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434
ChainResidueDetails
AGLY421
BGLY421

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PDB entries from 2024-04-24

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