6JBJ

Cryo-EM structure of human lysosomal cobalamin exporter ABCD4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005765	cellular_component	lysosomal membrane
A	0005777	cellular_component	peroxisome
A	0005778	cellular_component	peroxisomal membrane
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006635	biological_process	fatty acid beta-oxidation
A	0007031	biological_process	peroxisome organization
A	0009235	biological_process	cobalamin metabolic process
A	0015420	molecular_function	ABC-type vitamin B12 transporter activity
A	0015889	biological_process	cobalamin transport
A	0015910	biological_process	long-chain fatty acid import into peroxisome
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
A	0042760	biological_process	very long-chain fatty acid catabolic process
A	0042802	molecular_function	identical protein binding
A	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
A	0055085	biological_process	transmembrane transport
A	0140359	molecular_function	ABC-type transporter activity
B	0000166	molecular_function	nucleotide binding
B	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005765	cellular_component	lysosomal membrane
B	0005777	cellular_component	peroxisome
B	0005778	cellular_component	peroxisomal membrane
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0006635	biological_process	fatty acid beta-oxidation
B	0007031	biological_process	peroxisome organization
B	0009235	biological_process	cobalamin metabolic process
B	0015420	molecular_function	ABC-type vitamin B12 transporter activity
B	0015889	biological_process	cobalamin transport
B	0015910	biological_process	long-chain fatty acid import into peroxisome
B	0016020	cellular_component	membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
B	0042760	biological_process	very long-chain fatty acid catabolic process
B	0042802	molecular_function	identical protein binding
B	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
B	0055085	biological_process	transmembrane transport
B	0140359	molecular_function	ABC-type transporter activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue ATP A 701

Chain	Residue
A	ALA396
A	TRP438
A	GLN461
B	ARG508
B	ASP522
B	VAL523
B	SER525
B	PRO526
B	GLY527
B	GLU528
A	THR423
A	GLY424
A	THR425
A	GLY426
A	LYS427
A	THR428
A	SER429
A	ARG432

---

site_id	AC2
Number of Residues	18
Details	binding site for residue ATP B 701

Chain	Residue
A	ARG508
A	ASP522
A	VAL523
A	SER525
A	PRO526
A	GLY527
A	GLU528
B	ALA396
B	THR423
B	GLY424
B	THR425
B	GLY426
B	LYS427
B	THR428
B	SER429
B	ARG432
B	TRP438
B	GLN461

---

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSPGEMQRLSFARLF

Chain	Residue	Details
A	LEU524-PHE538

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	200
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	586
Details	Domain: {"description":"ABC transmembrane type-1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	428
Details	Domain: {"description":"ABC transporter","evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---