6J4V
Structural basis of tubulin detyrosination by vasohibins-SVBP enzyme complex and functional implications
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Tubulinyl-Tyr carboxypeptidase 2 | polymer | 251 | 29322.4 | 1 | UniProt (Q86V25) Pfam (PF14822) In PDB | Homo sapiens (Human) | Vasohibin-2,Vasohibin-like protein |
| 2 | B | Small vasohibin-binding protein | polymer | 66 | 7805.9 | 1 | UniProt (Q8N300) Pfam (PF15674) In PDB | Homo sapiens (Human) | Coiled coil domain-containing protein 23 |
| 3 | C | Tubulin alpha-1B chain | polymer | 21 | 2323.3 | 1 | UniProt (P68363) In PDB | Homo sapiens (Human) | Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain |
| 4 | A | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 5 | A | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 6 | water | water | 18.0 | 239 | Chemie (HOH) |
Sequence modifications
B: 1 - 66 (UniProt: Q8N300)
C: 431 - 451 (UniProt: P68363)
| PDB | External Database | Details |
|---|---|---|
| Ser 58 | Cys 58 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Cys 450 | Glu 450 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 39451.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 558.3 | |
| All* | Total formula weight | 40009.9 |
