6J15

Complex structure of GY-5 Fab and PD-1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (C, D)	Programmed cell death protein 1	polymer	120	13487.0	2	UniProt (Q15116) Pfam (PF07686)	Homo sapiens (Human)	PD-1, hPD-1
2	C, E (H, A)	GY-5 heavy chain Fab	polymer	219	23941.7	2		Mus musculus
3	D, F (L, B)	GY-5 light chain Fab	polymer	216	23846.5	2		Mus musculus
4	G (E)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	1	In PDB GlyTouCan (G21290RB)
5	H (F)	alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		732.7	1	In PDB GlyTouCan (G47477HI)
6	I, J (C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)

Sequence modifications

C, D: 32 - 147 (UniProt: Q15116)

PDB	External Database	Details
Asp 28	-	expression tag
Gly 29	-	expression tag
Ile 30	-	expression tag
Gln 31	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	122550.4
Branched	Number of molecules	2
	Total formula weight	1303.2
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	124296.1

*Water molecules are not included.