6IW7
structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications for developing antimicrobial agents targeting Clp protease
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, F, H... (A, C, F, H, J...) | ATP-dependent Clp protease proteolytic subunit 2 | polymer | 202 | 22235.3 | 7 | UniProt (P9WPC2) Pfam (PF00574) UniProt (by SIFTS) (P9WPC3) | Mycobacterium tuberculosis CDC1551 | Endopeptidase Clp 2 |
| 2 | B, D, G, I, K... (B, D, I, K, M...) | ATP-dependent Clp protease proteolytic subunit 1 | polymer | 194 | 21065.9 | 7 | UniProt (P9WPC4) Pfam (PF00574) UniProt (by SIFTS) (P9WPC5) | Mycobacterium tuberculosis CDC1551 | Endopeptidase Clp 1 |
| 3 | BA, EA, GA, JA, LA... (H, I, J, K, L...) | (2S)-2-benzamido-4-methyl-pentanoic acid | non-polymer | 235.3 | 14 | Chemie (S0R) | |||
| 4 | AA, CA, FA, HA, KA... (F, H, I, J, K...) | LEUCINE | non-polymer | 131.2 | 14 | Chemie (LEU) | |||
| 5 | DA, IA, PA, Q, R... (I, K, N, B, G...) | 4-[(4-fluoro-2-methyl-3H-indol-5-yl)oxy]-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline | non-polymer | 450.5 | 7 | Chemie (AV3) | |||
| 6 | AB, BB, CB, DB, EB... (D, F, H, I, J...) | water | water | 18.0 | 187 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 14 |
| Total formula weight | 303108.8 | |
| Non-Polymers* | Number of molecules | 35 |
| Total formula weight | 8283.9 | |
| All* | Total formula weight | 311392.7 |
