6IUP

Crystal structure of FGFR4 kinase domain in complex with compound 5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Fibroblast growth factor receptor 4	polymer	322	35963.4	1	UniProt (P22455) Pfam (PF07714) In PDB	Homo sapiens (Human)	FGFR-4
2	A	N-{4-[4-amino-3-(3,5-dimethyl-1-benzofuran-2-yl)-7-oxo-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-2-yl]phenyl}prop-2-enamide	non-polymer		440.5	1	Chemie (AX0)
3	A	DIMETHYL SULFOXIDE	non-polymer		78.1	1	Chemie (DMS)
4		water	water		18.0	276	Chemie (HOH)

Sequence modifications

A: 445 - 753 (UniProt: P22455)

PDB	External Database	Details
Met 432	-	initiating methionine
Gly 433	-	expression tag
Ser 434	-	expression tag
Ser 435	-	expression tag
His 436	-	expression tag
His 437	-	expression tag
His 438	-	expression tag
His 439	-	expression tag
His 440	-	expression tag
His 441	-	expression tag
Ser 442	-	expression tag
Ser 443	-	expression tag
Gly 444	-	expression tag
Glu 664	Arg 664	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	35963.4
Non-Polymers*	Number of molecules	2
	Total formula weight	518.6
All*	Total formula weight	36482.0

*Water molecules are not included.