6IUP
Crystal structure of FGFR4 kinase domain in complex with compound 5
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Fibroblast growth factor receptor 4 | polymer | 322 | 35963.4 | 1 | UniProt (P22455) Pfam (PF07714) In PDB | Homo sapiens (Human) | FGFR-4 |
2 | A | N-{4-[4-amino-3-(3,5-dimethyl-1-benzofuran-2-yl)-7-oxo-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-2-yl]phenyl}prop-2-enamide | non-polymer | 440.5 | 1 | Chemie (AX0) | |||
3 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
4 | water | water | 18.0 | 276 | Chemie (HOH) |
Sequence modifications
A: 445 - 753 (UniProt: P22455)
PDB | External Database | Details |
---|---|---|
Met 432 | - | initiating methionine |
Gly 433 | - | expression tag |
Ser 434 | - | expression tag |
Ser 435 | - | expression tag |
His 436 | - | expression tag |
His 437 | - | expression tag |
His 438 | - | expression tag |
His 439 | - | expression tag |
His 440 | - | expression tag |
His 441 | - | expression tag |
Ser 442 | - | expression tag |
Ser 443 | - | expression tag |
Gly 444 | - | expression tag |
Glu 664 | Arg 664 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 35963.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 518.6 | |
All* | Total formula weight | 36482.0 |