6ITT

Crystal structure of unactivated c-KIT in complex with compound

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Mast/stem cell growth factor receptor Kit	polymer	331	37669.6	2	UniProt (P10721) Pfam (PF07714)	Homo sapiens (Human)	SCFR,Piebald trait protein,PBT,Proto-oncogene c-Kit,Tyrosine-protein kinase Kit,p145 c-kit,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
2	C, D (A, B)	N-(5-ethyl-1,2-oxazol-3-yl)-N'-[4-(2-{[6-(4-ethylpyrazin-1(4H)-yl)pyrimidin-4-yl]amino}-1,3-thiazol-5-yl)phenyl]urea	non-polymer		515.6	2	Chemie (AWO)
3	E, F (A, B)	water	water		18.0	235	Chemie (HOH)

Sequence modifications

A, B: 547 - 751 (UniProt: P10721)
A, B: 754 - 935 (UniProt: P10721)

PDB	External Database	Details
Thr 752	-	linker
Ser 753	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	75339.1
Non-Polymers*	Number of molecules	2
	Total formula weight	1031.2
All*	Total formula weight	76370.3

*Water molecules are not included.