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6ITM

Crystal structure of FXR in complex with agonist XJ034

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, C
(A, C)
Bile acid receptorpolymer24027949.12UniProt (Q96RI1)
Pfam (PF00104)
Homo sapiens (Human)Farnesoid X-activated receptor,Farnesol receptor HRR-1,Nuclear receptor subfamily 1 group H member 4,Retinoid X receptor-interacting protein 14,RXR-interacting protein 14
2B, D
(B, D)
HD3 Peptide from Nuclear receptor coactivator 1polymer141790.02UniProt (Q15788)Homo sapiensSRC-1 HD3
3E, F
(A, C)
1-adamantyl-[4-(5-chloranyl-2-methyl-phenyl)piperazin-1-yl]methanonenon-polymer372.92Chemie (AWL)
4G, H, I
(A, B, C)
waterwater18.033Chemie (HOH)
Sequence modifications
A, C: 257 - 486 (UniProt: Q96RI1)
PDBExternal DatabaseDetails
Met 247-expression tag
Gly 248-expression tag
His 249-expression tag
His 250-expression tag
His 251-expression tag
His 252-expression tag
His 253-expression tag
His 254-expression tag
Gly 255-expression tag
Ser 256-expression tag
Ala 291Glu 291engineered mutation
Ala 364Glu 364engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight59478.2
Non-Polymers*Number of molecules2
Total formula weight745.9
All*Total formula weight60224.1
*Water molecules are not included.

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PDB entries from 2025-07-09

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