6ITM

Crystal structure of FXR in complex with agonist XJ034

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004879	molecular_function	nuclear receptor activity
A	0032052	molecular_function	bile acid binding
A	0038183	biological_process	bile acid signaling pathway
C	0004879	molecular_function	nuclear receptor activity
C	0032052	molecular_function	bile acid binding
C	0038183	biological_process	bile acid signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue AWL A 501

Chain	Residue
A	PHE298
A	ILE371
A	TYR375
A	TYR383
A	MET464
A	LEU301
A	THR302
A	MET304
A	HIS308
A	MET342
A	SER346
A	ILE349
A	LEU362

---

site_id	AC2
Number of Residues	8
Details	binding site for residue AWL C 501

Chain	Residue
C	PHE298
C	THR302
C	MET304
C	HIS308
C	SER346
C	ILE366
C	TYR375
C	TRP483

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PDB","id":"6HL1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by PKC/PRKCZ","evidences":[{"source":"PubMed","id":"18668687","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"23546875","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Motif: {"description":"LXXLL motif 5"}

Chain

Residue

Details

---