6ITM

Crystal structure of FXR in complex with agonist XJ034

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004879	molecular_function	nuclear receptor activity
A	0032052	molecular_function	bile acid binding
A	0038183	biological_process	bile acid signaling pathway
C	0004879	molecular_function	nuclear receptor activity
C	0032052	molecular_function	bile acid binding
C	0038183	biological_process	bile acid signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue AWL A 501

Chain	Residue
A	PHE298
A	ILE371
A	TYR375
A	TYR383
A	MET464
A	LEU301
A	THR302
A	MET304
A	HIS308
A	MET342
A	SER346
A	ILE349
A	LEU362

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site_id	AC2
Number of Residues	8
Details	binding site for residue AWL C 501

Chain	Residue
C	PHE298
C	THR302
C	MET304
C	HIS308
C	SER346
C	ILE366
C	TYR375
C	TRP483

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0007744|PDB:6HL1

Chain	Residue	Details
A	ARG345
A	TYR375
A	TYR383
A	HIS461
C	ARG345
C	TYR375
C	TYR383
C	HIS461

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by PKC/PRKCZ => ECO:0000305|PubMed:18668687

Chain	Residue	Details
A	THR456
C	THR456

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site_id	SWS_FT_FI3
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000305|PubMed:23546875

Chain	Residue	Details
C	LYS289
A	LYS289

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