6IRA

Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 7.8

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	D, B	Glutamate receptor ionotropic, NMDA 2A	polymer	853	95603.9	2	UniProt (Q12879) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF00497) In PDB	Homo sapiens (Human)	GluN2A,Glutamate [NMDA] receptor subunit epsilon-1,N-methyl D-aspartate receptor subtype 2A,hNR2A
2	A, C	Glutamate receptor ionotropic, NMDA 1	polymer	847	95336.2	2	UniProt (Q05586) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF00497) In PDB	Homo sapiens (Human)	GluN1,Glutamate [NMDA] receptor subunit zeta-1,N-methyl-D-aspartate receptor subunit NR1,NMD-R1

Sequence modifications

D, B: 1 - 842 (UniProt: Q12879)

PDB	External Database	Details
Arg 656	Glu 656	engineered mutation
Arg 657	Glu 657	engineered mutation
Lys 843	-	expression tag
Ser 844	-	expression tag
Arg 845	-	expression tag
Ala 846	-	expression tag
Glu 847	-	expression tag
Ala 848	-	expression tag
Lys 849	-	expression tag
Arg 850	-	expression tag
Met 851	-	expression tag
Lys 852	-	expression tag
Gly 853	-	expression tag

A, C: 1 - 847 (UniProt: Q05586)

PDB	External Database	Details
Arg 612	Gly 612	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	381880.2
All*	Total formula weight	381880.2

*Water molecules are not included.