6IRA

Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 7.8

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
A	0038023	molecular_function	signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
B	0038023	molecular_function	signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
C	0038023	molecular_function	signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
D	0038023	molecular_function	signaling receptor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1408
Details	TOPO_DOM: Extracellular => ECO:0000250|UniProtKB:P35439

Chain	Residue	Details
A	ARG19-GLN559
A	THR648-ASN812
C	ARG19-GLN559
C	THR648-ASN812

---

site_id	SWS_FT_FI2
Number of Residues	112
Details	TRANSMEM: Helical => ECO:0000250|UniProtKB:P35439

Chain	Residue	Details
A	SER560-LEU580
A	ILE631-TYR647
A	MET813-ILE833
C	SER560-LEU580
C	ILE631-TYR647
C	MET813-ILE833

---

site_id	SWS_FT_FI3
Number of Residues	52
Details	TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:P35439

Chain	Residue	Details
A	ASP581-THR602
A	ARG625-ARG630
C	ASP581-THR602
C	ARG625-ARG630

---

site_id	SWS_FT_FI4
Number of Residues	42
Details	INTRAMEM: Discontinuously helical => ECO:0000250|UniProtKB:A0A1L8F5J9

Chain	Residue	Details
A	LEU603-PRO624
C	LEU603-PRO624

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28105280, ECO:0007744|PDB:5H8F, ECO:0007744|PDB:5H8H, ECO:0007744|PDB:5H8N, ECO:0007744|PDB:5H8Q, ECO:0007744|PDB:5I2K, ECO:0007744|PDB:5I2N, ECO:0007744|PDB:5KCJ, ECO:0007744|PDB:5KDT, ECO:0007744|PDB:5TP9, ECO:0007744|PDB:5TPA

Chain	Residue	Details
A	PRO516
B	ASP282
B	SER689
B	TYR730
A	ARG523
A	SER688
A	ASP732
C	PRO516
C	ARG523
C	SER688
C	ASP732
B	GLU266

---

site_id	SWS_FT_FI6
Number of Residues	24
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN61
A	ASN491
A	ASN674
A	ASN771
C	ASN61
C	ASN203
C	ASN239
C	ASN276
C	ASN300
C	ASN350
C	ASN368
A	ASN203
C	ASN440
C	ASN471
C	ASN491
C	ASN674
C	ASN771
A	ASN239
A	ASN276
A	ASN300
A	ASN350
A	ASN368
A	ASN440
A	ASN471

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	SITE: Functional determinant of NMDA receptors => ECO:0000250

Chain	Residue	Details
D	ASN614
B	ASN614

---

site_id	SWS_FT_FI8
Number of Residues	14
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
D	ASN75
B	ASN380
B	ASN443
B	ASN444
B	ASN542
B	ASN687
D	ASN340
D	ASN380
D	ASN443
D	ASN444
D	ASN542
D	ASN687
B	ASN75
B	ASN340

---