6IRA
Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 7.8
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0038023 | molecular_function | signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0038023 | molecular_function | signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| C | 0016020 | cellular_component | membrane |
| C | 0038023 | molecular_function | signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| D | 0016020 | cellular_component | membrane |
| D | 0038023 | molecular_function | signaling receptor activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1404 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:34186027, ECO:0007744|PDB:7EOQ |
| Chain | Residue | Details |
| A | ARG19-GLN559 | |
| A | ALA649-GLU811 | |
| C | ARG19-GLN559 | |
| C | ALA649-GLU811 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 126 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:34186027, ECO:0007744|PDB:7EOQ |
| Chain | Residue | Details |
| A | SER560-LEU580 | |
| A | SER628-THR648 | |
| A | ASN812-ILE835 | |
| C | SER560-LEU580 | |
| C | SER628-THR648 | |
| C | ASN812-ILE835 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 68 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:34186027, ECO:0007744|PDB:7EOQ |
| Chain | Residue | Details |
| A | ASP581-SER604 | |
| A | ASN616-PHE627 | |
| C | ASP581-SER604 | |
| C | ASN616-PHE627 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | INTRAMEM: Discontinuously helical => ECO:0000269|PubMed:34186027, ECO:0007744|PDB:7EOQ |
| Chain | Residue | Details |
| A | SER605-LEU615 | |
| C | SER605-LEU615 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28105280, ECO:0007744|PDB:5H8F, ECO:0007744|PDB:5H8H, ECO:0007744|PDB:5H8N, ECO:0007744|PDB:5H8Q, ECO:0007744|PDB:5I2K, ECO:0007744|PDB:5I2N, ECO:0007744|PDB:5KCJ, ECO:0007744|PDB:5KDT, ECO:0007744|PDB:5TP9, ECO:0007744|PDB:5TPA |
| Chain | Residue | Details |
| A | PRO516 | |
| C | PRO516 | |
| D | GLU266 | |
| D | ASP282 | |
| B | HIS44 | |
| B | HIS128 | |
| B | GLU266 | |
| B | ASP282 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:36959261, ECO:0007744|PDB:5H8F, ECO:0007744|PDB:5H8H, ECO:0007744|PDB:5H8N, ECO:0007744|PDB:5H8Q, ECO:0007744|PDB:5I2K, ECO:0007744|PDB:5I2N, ECO:0007744|PDB:5KCJ, ECO:0007744|PDB:5KDT, ECO:0007744|PDB:5TP9, ECO:0007744|PDB:5TPA, ECO:0007744|PDB:7YFF |
| Chain | Residue | Details |
| A | THR518 | |
| B | THR690 | |
| A | SER688 | |
| C | THR518 | |
| C | SER688 | |
| D | THR690 | |
| B | SER511 | |
| B | THR513 | |
| B | ARG518 | |
| B | SER689 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:36309015, ECO:0000269|PubMed:36959261, ECO:0000312|PDB:8E96, ECO:0007744|PDB:5H8F, ECO:0007744|PDB:5H8H, ECO:0007744|PDB:5H8N, ECO:0007744|PDB:5H8Q, ECO:0007744|PDB:5I2K, ECO:0007744|PDB:5I2N, ECO:0007744|PDB:5KCJ, ECO:0007744|PDB:5KDT, ECO:0007744|PDB:5TP9, ECO:0007744|PDB:5TPA, ECO:0007744|PDB:7YFR |
| Chain | Residue | Details |
| A | ARG523 | |
| C | ARG523 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:36309015, ECO:0000269|PubMed:36959261, ECO:0000312|PDB:8E96, ECO:0007744|PDB:5H8F, ECO:0007744|PDB:5H8H, ECO:0007744|PDB:5H8N, ECO:0007744|PDB:5H8Q, ECO:0007744|PDB:5I2K, ECO:0007744|PDB:5I2N, ECO:0007744|PDB:5KCJ, ECO:0007744|PDB:5KDT, ECO:0007744|PDB:5TP9, ECO:0007744|PDB:5TPA, ECO:0007744|PDB:7YFF |
| Chain | Residue | Details |
| A | ASP732 | |
| C | ASP732 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:36309015, ECO:0000312|PDB:8E92, ECO:0000312|PDB:8E93, ECO:0000312|PDB:8E94, ECO:0000312|PDB:8E97, ECO:0000312|PDB:8E98, ECO:0000312|PDB:8E99 |
| Chain | Residue | Details |
| A | ASN61 | |
| B | ASN542 | |
| C | ASN61 | |
| D | ASN443 | |
| D | ASN444 | |
| D | ASN542 | |
| B | ASN75 | |
| B | ASN380 | |
| B | ASN443 | |
| B | ASN444 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:36309015, ECO:0000269|PubMed:36959261, ECO:0000312|PDB:8E92, ECO:0000312|PDB:8E93, ECO:0000312|PDB:8E94, ECO:0000312|PDB:8E97, ECO:0007744|PDB:7YFR |
| Chain | Residue | Details |
| A | ASN203 | |
| C | ASN203 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:36309015, ECO:0000312|PDB:8E93, ECO:0000312|PDB:8E97 |
| Chain | Residue | Details |
| A | ASN239 | |
| C | ASN239 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:34186027, ECO:0000269|PubMed:36309015, ECO:0000312|PDB:8E92, ECO:0000312|PDB:8E93, ECO:0000312|PDB:8E94, ECO:0000312|PDB:8E96, ECO:0000312|PDB:8E97, ECO:0007744|PDB:7EOQ |
| Chain | Residue | Details |
| A | ASN276 | |
| C | ASN276 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN300 | |
| A | ASN440 | |
| A | ASN491 | |
| A | ASN674 | |
| C | ASN300 | |
| C | ASN440 | |
| C | ASN491 | |
| C | ASN674 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:36309015, ECO:0000312|PDB:8E93, ECO:0000312|PDB:8E94, ECO:0000312|PDB:8E96, ECO:0000312|PDB:8E97 |
| Chain | Residue | Details |
| A | ASN350 | |
| C | ASN350 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:36309015, ECO:0000312|PDB:8E92, ECO:0000312|PDB:8E94, ECO:0000312|PDB:8E97 |
| Chain | Residue | Details |
| A | ASN368 | |
| C | ASN368 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:34186027, ECO:0000269|PubMed:36309015, ECO:0000269|PubMed:36959261, ECO:0000312|PDB:8E93, ECO:0000312|PDB:8E94, ECO:0000312|PDB:8E97, ECO:0000312|PDB:8E98, ECO:0007744|PDB:7EOQ, ECO:0007744|PDB:7YFR |
| Chain | Residue | Details |
| A | ASN471 | |
| C | ASN471 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:34186027, ECO:0000269|PubMed:36309015, ECO:0000312|PDB:8E92, ECO:0000312|PDB:8E93, ECO:0000312|PDB:8E94, ECO:0000312|PDB:8E96, ECO:0000312|PDB:8E97, ECO:0000312|PDB:8E98, ECO:0000312|PDB:8E99, ECO:0007744|PDB:7EOQ |
| Chain | Residue | Details |
| A | ASN771 | |
| C | ASN771 |
