6INE
Crystal Structure of human ASH1L-MRG15 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone-lysine N-methyltransferase ASH1L | polymer | 267 | 31208.6 | 1 | UniProt (Q9NR48) Pfam (PF17907) Pfam (PF00856) | Homo sapiens (Human) | ASH1-like protein,huASH1,Absent small and homeotic disks protein 1 homolog,Lysine N-methyltransferase 2H |
| 2 | B (B) | Mortality factor 4-like protein 1 | polymer | 177 | 20458.4 | 1 | UniProt (Q9UBU8) Pfam (PF05712) | Homo sapiens (Human) | MORF-related gene 15 protein,Protein MSL3-1,Transcription factor-like protein MRG15 |
| 3 | C, D, E (A) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 4 | F (A) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) | |||
| 5 | G (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | H, I (A, B) | water | water | 18.0 | 67 | Chemie (HOH) |
Sequence modifications
A: 2026 - 2288 (UniProt: Q9NR48)
B: 151 - 323 (UniProt: Q9UBU8)
| PDB | External Database | Details |
|---|---|---|
| Met 2022 | - | expression tag |
| Ala 2023 | - | expression tag |
| Asp 2024 | - | expression tag |
| Pro 2025 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 147 | - | expression tag |
| Ser 148 | - | expression tag |
| Asp 149 | - | expression tag |
| Pro 150 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 51667.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 686.8 | |
| All* | Total formula weight | 52353.8 |
