6INE

Crystal Structure of human ASH1L-MRG15 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0042054	molecular_function	histone methyltransferase activity
B	0005634	cellular_component	nucleus
B	0006325	biological_process	chromatin organization
B	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 2301

Chain	Residue
A	CYS2220
A	CYS2268
A	CYS2270
A	CYS2275

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site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 2302

Chain	Residue
A	CYS2104
A	CYS2117
A	CYS2122
A	CYS2128

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site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 2303

Chain	Residue
A	CYS2093
A	CYS2104
A	CYS2108
A	CYS2091

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site_id	AC4
Number of Residues	14
Details	binding site for residue SAM A 2304

Chain	Residue
A	LYS2150
A	TRP2152
A	ASP2192
A	HIS2193
A	TYR2194
A	ARG2214
A	PHE2215
A	ASN2217
A	HIS2218
A	TYR2255
A	GLN2266
A	LEU2267
A	LYS2269
A	ILE2279

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site_id	AC5
Number of Residues	5
Details	binding site for residue GOL B 401

Chain	Residue
A	LYS2070
B	PHE182
B	LEU184
B	GLN241
B	GLU244

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