6IN3
Crystal structure of DOT1L in complex with 18-Crown-6
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone-lysine N-methyltransferase, H3 lysine-79 specific | polymer | 336 | 39050.3 | 1 | UniProt (Q8TEK3) Pfam (PF08123) | Homo sapiens (Human) | DOT1-like protein,Histone H3-K79 methyltransferase,H3-K79-HMTase,Lysine N-methyltransferase 4 |
| 2 | B (A) | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE | non-polymer | 264.3 | 1 | Chemie (O4B) | |||
| 3 | C (A) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) | |||
| 4 | D, E, F, G, H (A) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 5 | I (A) | water | water | 18.0 | 103 | Chemie (HOH) |
Sequence modifications
A: 4 - 330 (UniProt: Q8TEK3)
| PDB | External Database | Details |
|---|---|---|
| Met 3 | - | initiating methionine |
| Leu 331 | - | expression tag |
| Glu 332 | - | expression tag |
| His 333 | - | expression tag |
| His 334 | - | expression tag |
| His 335 | - | expression tag |
| His 336 | - | expression tag |
| His 337 | - | expression tag |
| His 338 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39050.3 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1129.0 | |
| All* | Total formula weight | 40179.4 |
