6ILD

Crystal Structure of Human LysRS: P38/AIMP2 Complex II

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Lysine--tRNA ligase	polymer	513	59240.1	2	UniProt (Q15046) Pfam (PF01336) Pfam (PF00152)	Homo sapiens (Human)	Lysyl-tRNA synthetase,LysRS
2	C (C)	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	polymer	44	5154.0	1	UniProt (Q13155) Pfam (PF16780)	Homo sapiens (Human)	Multisynthase complex auxiliary component p38
3	D, I (A, B)	LYSINE	non-polymer		147.2	2	Chemie (LYS)
4	E, F, H, K, L (A, B)	GLYCEROL	non-polymer		92.1	5	Chemie (GOL)
5	G, J (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
6	M (B)	5'-O-[(S)-hydroxy(methyl)phosphoryl]adenosine	non-polymer		345.2	1	Chemie (45A)
7	N, O, P (A, B, C)	water	water		18.0	910	Chemie (HOH)

Sequence modifications

A, B: 70 - 581 (UniProt: Q15046)

PDB	External Database	Details
Met 69	-	initiating methionine

C: 1 - 36 (UniProt: Q13155)

PDB	External Database	Details
Leu 37	-	expression tag
Glu 38	-	expression tag
His 39	-	expression tag
His 40	-	expression tag
His 41	-	expression tag
His 42	-	expression tag
His 43	-	expression tag
His 44	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	123634.2
Non-Polymers*	Number of molecules	10
	Total formula weight	1148.7
All*	Total formula weight	124782.9

*Water molecules are not included.