6IL3

Crystal structure of the FLT3 kinase bound to a small molecule inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Receptor-type tyrosine-protein kinase FLT3	polymer	370	43044.8	1	UniProt (P36888) Pfam (PF07714)	Homo sapiens (Human)	FL cytokine receptor,Fetal liver kinase-2,FLK-2,Fms-like tyrosine kinase 3,FLT-3,Stem cell tyrosine kinase 1,STK-1
2	B (A)	7-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-(pyridin-2-yl)imidazo[1,2-a]pyridine	non-polymer		305.3	1	Chemie (A9R)
3	C, D, E, F (A)	PHOSPHATE ION	non-polymer		95.0	4	Chemie (PO4)
4	G, H (A)	3-CYCLOHEXYL-1-PROPYLSULFONIC ACID	non-polymer		221.3	2	Chemie (CXS)
5	I, J, K, L, M... (A)	GLYCEROL	non-polymer		92.1	10	Chemie (GOL)
6	S, T, U (A)	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL)
7	V (A)	water	water		18.0	33	Chemie (HOH)

Sequence modifications

A: 564 - 710 (UniProt: P36888)

PDB	External Database	Details
Met 538	-	expression tag
Ser 539	-	expression tag
Tyr 540	-	expression tag
Tyr 541	-	expression tag
His 542	-	expression tag
His 543	-	expression tag
His 544	-	expression tag
His 545	-	expression tag
His 546	-	expression tag
His 547	-	expression tag
Asp 548	-	expression tag
Tyr 549	-	expression tag
Asp 550	-	expression tag
Ile 551	-	expression tag
Pro 552	-	expression tag
Thr 553	-	expression tag
Thr 554	-	expression tag
Glu 555	-	expression tag
Asn 556	-	expression tag
Leu 557	-	expression tag
Tyr 558	-	expression tag
Phe 559	-	expression tag
Gln 560	-	expression tag
Ser 561	-	expression tag
Ile 562	-	expression tag
Ala 563	-	expression tag

A: 762 - 958 (UniProt: P36888)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	43044.8
Non-Polymers*	Number of molecules	20
	Total formula weight	2155.2
All*	Total formula weight	45200.0

*Water molecules are not included.