6IIV

Crystal structure of the human thromboxane A2 receptor bound to daltroban

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Soluble cytochrome b562,Thromboxane A2 receptor,Rubredoxin,Thromboxane A2 receptor	polymer	484	53242.2	1	UniProt (P0ABE7) UniProt (P21731) UniProt (P00268) Pfam (PF07361) Pfam (PF00001) Pfam (PF00301)	Escherichia coli	Cytochrome b-562,TXA2-R,Prostanoid TP receptor,Rd,TXA2-R,Prostanoid TP receptor
2	B (A)	2-[4-[2-[(4-chlorophenyl)sulfonylamino]ethyl]phenyl]ethanoic acid	non-polymer		353.8	1	Chemie (A90)
3	C (A)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
4	D (A)	CHOLESTEROL	non-polymer		386.7	1	Chemie (CLR)
5	E (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)

Sequence modifications

A: 1001 - 1106 (UniProt: P0ABE7)

PDB	External Database	Details
Asp 991	-	expression tag
Tyr 992	-	expression tag
Lys 993	-	expression tag
Asp 994	-	expression tag
Asp 995	-	expression tag
Asp 996	-	expression tag
Asp 997	-	expression tag
Gly 998	-	expression tag
Ala 999	-	expression tag
Pro 1000	-	expression tag
Trp 1007	Met 29	engineered mutation
Ile 1102	His 124	engineered mutation
Leu 1106	Arg 128	engineered mutation

A: 10 - 228 (UniProt: P21731)
A: 2001 - 2054 (UniProt: P00268)
A: 237 - 323 (UniProt: P21731)

PDB	External Database	Details
Ala 247	Leu 247	engineered mutation
Glu 324	-	expression tag
Phe 325	-	expression tag
Leu 326	-	expression tag
Glu 327	-	expression tag
Val 328	-	expression tag
Leu 329	-	expression tag
Phe 330	-	expression tag
Gln 331	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	53242.2
Non-Polymers*	Number of molecules	4
	Total formula weight	898.0
All*	Total formula weight	54140.2

*Water molecules are not included.