6IGK

Crystal Structure of human ETB receptor in complex with Endothelin-3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Endothelin receptor type B,Endolysin,Endothelin receptor type B	polymer	498	55956.7	1	UniProt (P24530) UniProt (A0A097J809) Pfam (PF00001)	Homo sapiens (Human)	ET-BR,Endothelin receptor non-selective type,Lysis protein,Lysozyme,Muramidase
2	B (B)	Endothelin-3	polymer	21	2650.1	1	UniProt (P14138) Pfam (PF00322)	Homo sapiens	ET-3,Preproendothelin-3,PPET3
3	C, D, E, F, G... (A)	(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate	non-polymer		356.5	12	Chemie (OLC)
4	O (A)	CITRIC ACID	non-polymer		192.1	1	Chemie (CIT)
5	P, Q (A, B)	water	water		18.0	175	Chemie (HOH)

Sequence modifications

A: 66 - 303 (UniProt: P24530)

PDB	External Database	Details
Gly 63	-	expression tag
Gly 64	-	expression tag
Gly 65	-	expression tag
Tyr 124	Arg 124	engineered mutation
Ala 154	Asp 154	engineered mutation
Ala 270	Lys 270	engineered mutation

A: 1000 - 1159 (UniProt: A0A097J809)

PDB	External Database	Details
Thr 1052	Cys 54	engineered mutation
Ala 1095	Cys 97	engineered mutation

A: 311 - 407 (UniProt: P24530)

PDB	External Database	Details
Ala 342	Ser 342	engineered mutation
Ala 381	Ile 381	engineered mutation
Ala 396	Cys 396	engineered mutation
Ala 400	Cys 400	engineered mutation
Ala 405	Cys 405	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	58606.8
Non-Polymers*	Number of molecules	13
	Total formula weight	4470.6
All*	Total formula weight	63077.4

*Water molecules are not included.