6IGK
Crystal Structure of human ETB receptor in complex with Endothelin-3
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Endothelin receptor type B,Endolysin,Endothelin receptor type B | polymer | 498 | 55956.7 | 1 | UniProt (P24530) UniProt (A0A097J809) Pfam (PF00001) In PDB | Homo sapiens (Human) | ET-BR,Endothelin receptor non-selective type,Lysis protein,Lysozyme,Muramidase |
2 | B | Endothelin-3 | polymer | 21 | 2650.1 | 1 | UniProt (P14138) Pfam (PF00322) In PDB | Homo sapiens | ET-3,Preproendothelin-3,PPET3 |
3 | A | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 12 | Chemie (OLC) | |||
4 | A | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) | |||
5 | water | water | 18.0 | 175 | Chemie (HOH) |
Sequence modifications
A: 66 - 303 (UniProt: P24530)
A: 1000 - 1159 (UniProt: A0A097J809)
A: 311 - 407 (UniProt: P24530)
PDB | External Database | Details |
---|---|---|
Gly 63 | - | expression tag |
Gly 64 | - | expression tag |
Gly 65 | - | expression tag |
Tyr 124 | Arg 124 | engineered mutation |
Ala 154 | Asp 154 | engineered mutation |
Ala 270 | Lys 270 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Thr 1052 | Cys 54 | engineered mutation |
Ala 1095 | Cys 97 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ala 342 | Ser 342 | engineered mutation |
Ala 381 | Ile 381 | engineered mutation |
Ala 396 | Cys 396 | engineered mutation |
Ala 400 | Cys 400 | engineered mutation |
Ala 405 | Cys 405 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 58606.8 | |
Non-Polymers* | Number of molecules | 13 |
Total formula weight | 4470.6 | |
All* | Total formula weight | 63077.4 |