6IFJ
Structure of bispecific Fc
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Immunoglobulin gamma-1 heavy chain | polymer | 232 | 26154.7 | 1 | UniProt (P0DOX5) Pfam (PF07654) | Homo sapiens (Human) | Immunoglobulin gamma-1 heavy chain NIE |
| 2 | B (B) | Immunoglobulin gamma-1 heavy chain | polymer | 232 | 26126.5 | 1 | UniProt (P0DOX5) Pfam (PF07654) | Homo sapiens (Human) | Immunoglobulin gamma-1 heavy chain NIE |
| 3 | C, D (C, D) | 13-mer peptide | polymer | 13 | 1533.7 | 2 | synthetic construct | ||
| 4 | E, F (E, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1260.2 | 2 | In PDB GlyTouCan (G45889JQ) | |||
| 5 | G, H, I, J, K (A, B) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 6 | L, M, N, O (A, B, C, D) | water | water | 18.0 | 350 | Chemie (HOH) |
Sequence modifications
A: 216 - 447 (UniProt: P0DOX5)
B: 216 - 447 (UniProt: P0DOX5)
| PDB | External Database | Details |
|---|---|---|
| Lys 357 | Glu 359 | engineered mutation |
| Arg 409 | Lys 411 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Glu 370 | Lys 372 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 55348.7 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 2520.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 460.5 | |
| All* | Total formula weight | 58329.5 |
