6IBY
Human PFKFB3 in complex with a N-Aryl 6-Aminoquinoxaline inhibitor 6
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | polymer | 428 | 49789.8 | 1 | UniProt (Q16875) Pfam (PF01591) Pfam (PF00300) In PDB | Homo sapiens (Human) | PFK/FBPase 3,6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme,Renal carcinoma antigen NY-REN-56,iPFK-2 |
| 2 | A | 3-[[8-(1-methylindol-6-yl)quinoxalin-6-yl]amino]-~{N}-[(3~{S})-1-methylpyrrolidin-3-yl]pyridine-4-carboxamide | non-polymer | 477.6 | 1 | Chemie (HAT) | |||
| 3 | A | PYROPHOSPHATE 2- | non-polymer | 176.0 | 1 | Chemie (POP) | |||
| 4 | A | CITRATE ANION | non-polymer | 189.1 | 1 | Chemie (FLC) | |||
| 5 | A | 6-O-phosphono-beta-D-fructofuranose | non-polymer | 260.1 | 1 | Chemie (F6P) | |||
| 6 | A | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 1 | Chemie (BME) | |||
| 7 | A | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 8 | water | water | 18.0 | 142 | Chemie (HOH) |
Sequence modifications
A: 3 - 446 (UniProt: Q16875)
| PDB | External Database | Details |
|---|---|---|
| - | Val 17 | deletion |
| - | Asp 18 | deletion |
| - | His 19 | deletion |
| - | Arg 20 | deletion |
| - | Pro 21 | deletion |
| - | Ser 22 | deletion |
| - | Leu 23 | deletion |
| - | Pro 24 | deletion |
| - | Arg 25 | deletion |
| - | Ser 26 | deletion |
| - | Cys 27 | deletion |
| - | Gly 28 | deletion |
| - | Pro 29 | deletion |
| - | Lys 30 | deletion |
| - | Leu 31 | deletion |
| - | Thr 32 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 49789.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1275.9 | |
| All* | Total formula weight | 51065.6 |
