6IBY

Human PFKFB3 in complex with a N-Aryl 6-Aminoquinoxaline inhibitor 6

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0003873	molecular_function	6-phosphofructo-2-kinase activity
A	0005524	molecular_function	ATP binding
A	0006000	biological_process	fructose metabolic process
A	0006003	biological_process	fructose 2,6-bisphosphate metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00175
Number of Residues	10
Details	PG_MUTASE Phosphoglycerate mutase family phosphohistidine signature. LcRHGEnEhN

Chain	Residue	Details
A	LEU250-ASN259

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Tele-phosphohistidine intermediate","evidences":[{"source":"PubMed","id":"22275052","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"22275052","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16316985","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17499765","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22275052","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16316985","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25849762","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P07953","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	3
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"22275052","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details