6IBX
Human PFKFB3 in complex with a N-Aryl 6-Aminoquinoxaline inhibitor 5
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | polymer | 429 | 49888.9 | 1 | UniProt (Q16875) Pfam (PF01591) Pfam (PF00300) In PDB | Homo sapiens (Human) | PFK/FBPase 3,6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme,Renal carcinoma antigen NY-REN-56,iPFK-2 |
2 | A | 3-[[8-(1-methylindol-6-yl)quinoxalin-6-yl]amino]-~{N}-[(3~{S})-1-methylpiperidin-3-yl]pyridine-4-carboxamide | non-polymer | 491.6 | 1 | Chemie (H9Z) | |||
3 | A | PYROPHOSPHATE 2- | non-polymer | 176.0 | 1 | Chemie (POP) | |||
4 | A | CITRATE ANION | non-polymer | 189.1 | 1 | Chemie (FLC) | |||
5 | A | 6-O-phosphono-beta-D-fructofuranose | non-polymer | 260.1 | 1 | Chemie (F6P) | |||
6 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
7 | water | water | 18.0 | 231 | Chemie (HOH) |
Sequence modifications
A: 3 - 446 (UniProt: Q16875)
PDB | External Database | Details |
---|---|---|
- | Asp 18 | deletion |
- | His 19 | deletion |
- | Arg 20 | deletion |
- | Pro 21 | deletion |
- | Ser 22 | deletion |
- | Leu 23 | deletion |
- | Pro 24 | deletion |
- | Arg 25 | deletion |
- | Ser 26 | deletion |
- | Cys 27 | deletion |
- | Gly 28 | deletion |
- | Pro 29 | deletion |
- | Lys 30 | deletion |
- | Leu 31 | deletion |
- | Thr 32 | deletion |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 49888.9 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 1194.9 | |
All* | Total formula weight | 51083.8 |