6IBX

Human PFKFB3 in complex with a N-Aryl 6-Aminoquinoxaline inhibitor 5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0003873	molecular_function	6-phosphofructo-2-kinase activity
A	0005524	molecular_function	ATP binding
A	0006000	biological_process	fructose metabolic process
A	0006003	biological_process	fructose 2,6-bisphosphate metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00175
Number of Residues	10
Details	PG_MUTASE Phosphoglycerate mutase family phosphohistidine signature. LcRHGEnEhN

Chain	Residue	Details
A	LEU250-ASN259

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255

Chain	Residue	Details
A	PHE139
A	ILE169

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Tele-phosphohistidine intermediate => ECO:0000269|PubMed:22275052

Chain	Residue	Details
A	SER268

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:22275052

Chain	Residue	Details
A	ARG337

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:16316985, ECO:0000269|PubMed:17499765, ECO:0000269|PubMed:22275052

Chain	Residue	Details
A	ARG56
A	ASN178
A	CYS439

---

site_id	SWS_FT_FI5
Number of Residues	7
Details	BINDING: BINDING => ECO:0000269|PubMed:16316985

Chain	Residue	Details
A	PRO89
A	LEU113
A	LYS141
A	ALA147
A	MET183
A	LYS204
A	ASP208

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:25849762

Chain	Residue	Details
A	ASP267
A	GLY274
A	ALA280
A	GLU348
A	TYR362
A	VAL366
A	GLU377
A	ALA403

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P07953

Chain	Residue	Details
A	GLY359
A	PRO407

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	SITE: Transition state stabilizer => ECO:0000269|PubMed:22275052

Chain	Residue	Details
A	ASP267
A	GLY274
A	SER402

---