6IBB

Crystal structure of the rat isoform of the succinate receptor SUCNR1 (GPR91) in complex with a nanobody

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Succinate receptor 1	polymer	342	39842.8	2	UniProt (Q6IYF9) Pfam (PF00001) In PDB	Rattus norvegicus (Norway Rat)	G-protein coupled receptor 91
2	B, D	Nanobody6	polymer	142	15527.1	2		Vicugna pacos (Alpaca)
3	A, C	(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate	non-polymer		356.5	15	Chemie (OLC)
4	A, C	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5	A	(2~{S},5~{R})-hexane-2,5-diol	non-polymer		118.2	1	Chemie (H95)
6	C	CHOLESTEROL	non-polymer		386.7	1	Chemie (CLR)
7		water	water		18.0	299	Chemie (HOH)

Sequence modifications

A, C: 2 - 317 (UniProt: Q6IYF9)

PDB	External Database	Details
Asp -6	-	expression tag
Tyr -5	-	expression tag
Lys -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Asp -1	-	expression tag
Asp 0	-	expression tag
Lys 1	-	expression tag
Leu 318	-	expression tag
Glu 319	-	expression tag
Val 320	-	expression tag
Leu 321	-	expression tag
Phe 322	-	expression tag
Gln 323	-	expression tag
Gly 324	-	expression tag
Pro 325	-	expression tag
His 326	-	expression tag
His 327	-	expression tag
His 328	-	expression tag
His 329	-	expression tag
His 330	-	expression tag
His 331	-	expression tag
His 332	-	expression tag
His 333	-	expression tag
His 334	-	expression tag
His 335	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	110739.8
Non-Polymers*	Number of molecules	19
	Total formula weight	6037.1
All*	Total formula weight	116777.0

*Water molecules are not included.