6IAR
Tricyclic indazoles a novel class of selective estrogen receptor degrader antagonists
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Estrogen receptor | polymer | 237 | 27092.8 | 1 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | A | 3-[4-[(6~{R})-7-(2-methylpropyl)-3,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]phenyl]propanoic acid | non-polymer | 377.5 | 1 | Chemie (H8W) | |||
| 3 | water | water | 18.0 | 99 | Chemie (HOH) |
Sequence modifications
A: 307 - 547 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| - | Ser 338 | deletion |
| - | Glu 339 | deletion |
| - | Ala 340 | deletion |
| Ser 381 | Cys 381 | conflict |
| Ser 417 | Cys 417 | conflict |
| - | Leu 462 | deletion |
| Ser 536 | Leu 536 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 27092.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 377.5 | |
| All* | Total formula weight | 27470.3 |
