6IAR
Tricyclic indazoles a novel class of selective estrogen receptor degrader antagonists
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue H8W A 601 |
| Chain | Residue |
| A | LEU346 |
| A | ALA491 |
| A | LYS492 |
| A | GLY494 |
| A | LEU495 |
| A | THR496 |
| A | LEU497 |
| A | GLN498 |
| A | GLN499 |
| A | GLN500 |
| A | VAL533 |
| A | THR347 |
| A | VAL534 |
| A | HOH702 |
| A | HOH719 |
| A | ALA350 |
| A | ASP351 |
| A | GLU353 |
| A | LEU387 |
| A | ARG394 |
| A | ILE487 |
| A | MET490 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9338790","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9600906","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ERE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by Tyr-kinases","evidences":[{"source":"PubMed","id":"7539106","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
