6I8Y
Crystal structure of Spindlin1 in complex with the Methyltransferase inhibitor A366
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Spindlin-1 | polymer | 222 | 25499.8 | 1 | UniProt (Q9Y657) Pfam (PF02513) | Homo sapiens (Human) | Ovarian cancer-related protein,Spindlin1 |
| 2 | B, C (A) | 5'-methoxy-6'-[3-(pyrrolidin-1-yl)propoxy]spiro[cyclobutane-1,3'-indol]-2'-amine | non-polymer | 329.4 | 2 | Chemie (2OD) | |||
| 3 | D, E (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 4 | F (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 5 | G (A) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 1 | Chemie (MPD) | |||
| 6 | H (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | I (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 8 | J (A) | water | water | 18.0 | 107 | Chemie (HOH) |
Sequence modifications
A: 49 - 262 (UniProt: Q9Y657)
| PDB | External Database | Details |
|---|---|---|
| Met 48 | - | initiating methionine |
| Ala 263 | - | expression tag |
| Glu 264 | - | expression tag |
| Asn 265 | - | expression tag |
| Leu 266 | - | expression tag |
| Tyr 267 | - | expression tag |
| Phe 268 | - | expression tag |
| Gln 269 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 25499.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1094.4 | |
| All* | Total formula weight | 26594.2 |
