6I8Y
Crystal structure of Spindlin1 in complex with the Methyltransferase inhibitor A366
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0007276 | biological_process | gamete generation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue 2OD A 301 |
| Chain | Residue |
| A | ASP95 |
| A | HOH456 |
| A | VAL118 |
| A | HIS139 |
| A | PHE141 |
| A | TRP151 |
| A | TYR170 |
| A | TYR177 |
| A | TYR179 |
| A | ASP184 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue 2OD A 302 |
| Chain | Residue |
| A | ARG51 |
| A | ASN52 |
| A | TRP62 |
| A | TRP72 |
| A | TYR91 |
| A | PHE94 |
| A | TYR98 |
| A | ASP116 |
| A | EDO303 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 303 |
| Chain | Residue |
| A | ARG51 |
| A | TYR98 |
| A | HIS252 |
| A | 2OD302 |
| A | HOH459 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue DMS A 305 |
| Chain | Residue |
| A | PRO81 |
| A | LYS186 |
| A | GLY188 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue MPD A 306 |
| Chain | Residue |
| A | ILE53 |
| A | PRO68 |
| A | TYR87 |
| A | HOH429 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 307 |
| Chain | Residue |
| A | THR169 |
| A | HOH407 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue NA A 308 |
| Chain | Residue |
| A | GLU138 |
| A | GLN217 |
| A | GLN269 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 63 |
| Details | Region: {"description":"Tudor-like domain 1","evidences":[{"source":"PubMed","id":"23077255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24589551","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Region: {"description":"Histone H3K4me3 and H3R8me2a binding","evidences":[{"source":"PubMed","id":"23077255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24589551","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 61 |
| Details | Region: {"description":"Tudor-like domain 2","evidences":[{"source":"PubMed","id":"23077255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24589551","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Site: {"description":"Histone H3K4me3 and H3R8me2a binding","evidences":[{"source":"PubMed","id":"23077255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24589551","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by AURKA","evidences":[{"source":"PubMed","id":"22258766","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
