6I8L
Crystal structure of Spindlin1 in complex with the inhibitor TD001851a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B | Spindlin-1 | polymer | 222 | 25499.8 | 1 | UniProt (Q9Y657) Pfam (PF02513) In PDB | Homo sapiens (Human) | Ovarian cancer-related protein,Spindlin1 |
| 2 | B | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 1 | Chemie (MPD) | |||
| 3 | B | (4R)-2-METHYLPENTANE-2,4-DIOL | non-polymer | 118.2 | 1 | Chemie (MRD) | |||
| 4 | B | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 5 | B | 5'-(cyclopropylmethoxy)-6'-[3-(1,3-dihydroisoindol-2-yl)propoxy]spiro[cyclopentane-1,3'-indole]-2'-amine | non-polymer | 431.6 | 1 | Chemie (H7Q) | |||
| 6 | B | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 7 | water | water | 18.0 | 96 | Chemie (HOH) |
Sequence modifications
B: 49 - 262 (UniProt: Q9Y657)
| PDB | External Database | Details |
|---|---|---|
| Met 48 | - | initiating methionine |
| Ala 263 | - | expression tag |
| Glu 264 | - | expression tag |
| Asn 265 | - | expression tag |
| Leu 266 | - | expression tag |
| Tyr 267 | - | expression tag |
| Phe 268 | - | expression tag |
| Gln 269 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 25499.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 781.5 | |
| All* | Total formula weight | 26281.3 |
