6I8L
Crystal structure of Spindlin1 in complex with the inhibitor TD001851a
Functional Information from GO Data
Chain | GOid | namespace | contents |
B | 0007276 | biological_process | gamete generation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | binding site for residue MPD B 301 |
Chain | Residue |
B | GLY153 |
B | GLU171 |
B | VAL255 |
B | HOH423 |
B | HOH425 |
site_id | AC2 |
Number of Residues | 3 |
Details | binding site for residue MRD B 302 |
Chain | Residue |
B | TRP62 |
B | TRP72 |
B | TYR98 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue DMS B 303 |
Chain | Residue |
B | TYR185 |
B | LYS186 |
B | GLY188 |
B | PRO81 |
site_id | AC4 |
Number of Residues | 11 |
Details | binding site for residue H7Q B 304 |
Chain | Residue |
B | ASP95 |
B | VAL118 |
B | ALA119 |
B | HIS139 |
B | PHE141 |
B | TRP151 |
B | TYR170 |
B | TYR177 |
B | TYR179 |
B | ASP184 |
B | HOH480 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 3 |
Details | SITE: Histone H3K4me3 and H3R8me2a binding |
Chain | Residue | Details |
B | ASP173 | |
B | GLN180 | |
B | ASP184 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by AURKA => ECO:0000269|PubMed:22258766 |
Chain | Residue | Details |
B | SER109 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by AURKA => ECO:0000269|PubMed:22258766, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
B | SER124 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
B | SER199 |