6I8L
Crystal structure of Spindlin1 in complex with the inhibitor TD001851a
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0007276 | biological_process | gamete generation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MPD B 301 |
| Chain | Residue |
| B | GLY153 |
| B | GLU171 |
| B | VAL255 |
| B | HOH423 |
| B | HOH425 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue MRD B 302 |
| Chain | Residue |
| B | TRP62 |
| B | TRP72 |
| B | TYR98 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue DMS B 303 |
| Chain | Residue |
| B | TYR185 |
| B | LYS186 |
| B | GLY188 |
| B | PRO81 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue H7Q B 304 |
| Chain | Residue |
| B | ASP95 |
| B | VAL118 |
| B | ALA119 |
| B | HIS139 |
| B | PHE141 |
| B | TRP151 |
| B | TYR170 |
| B | TYR177 |
| B | TYR179 |
| B | ASP184 |
| B | HOH480 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | SITE: Histone H3K4me3 and H3R8me2a binding |
| Chain | Residue | Details |
| B | ASP173 | |
| B | GLN180 | |
| B | ASP184 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by AURKA => ECO:0000269|PubMed:22258766 |
| Chain | Residue | Details |
| B | SER109 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by AURKA => ECO:0000269|PubMed:22258766, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER124 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER199 |
