6I83
Crystal structure of phosphorylated RET V804M tyrosine kinase domain complexed with PDD00018366
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Proto-oncogene tyrosine-protein kinase receptor Ret | polymer | 314 | 35820.3 | 1 | UniProt (P07949) Pfam (PF07714) In PDB | Homo sapiens (Human) | Cadherin family member 12,Proto-oncogene c-Ret |
| 2 | A | 4-[5-(pyridin-3-ylmethylamino)pyrazolo[1,5-a]pyrimidin-3-yl]benzamide | non-polymer | 344.4 | 1 | Chemie (H72) | |||
| 3 | A | FORMIC ACID | non-polymer | 46.0 | 15 | Chemie (FMT) | |||
| 4 | water | water | 18.0 | 89 | Chemie (HOH) |
Sequence modifications
A: 705 - 1013 (UniProt: P07949)
| PDB | External Database | Details |
|---|---|---|
| Gly 700 | - | expression tag |
| Pro 701 | - | expression tag |
| Leu 702 | - | expression tag |
| Ser 703 | - | expression tag |
| Leu 704 | - | expression tag |
| Met 804 | Val 804 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35820.3 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 1034.7 | |
| All* | Total formula weight | 36855.0 |
