6I83

Crystal structure of phosphorylated RET V804M tyrosine kinase domain complexed with PDD00018366

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue H72 A 1101

Chain	Residue
A	LEU730
A	GLY810
A	SER811
A	ARG878
A	LEU881
A	SER891
A	ASP892
A	PHE735
A	ALA756
A	LYS758
A	GLU775
A	MET804
A	GLU805
A	TYR806
A	ALA807

---

site_id	AC2
Number of Residues	8
Details	binding site for residue FMT A 1102

Chain	Residue
A	GLY700
A	PRO701
A	LEU702
A	SER703
A	GLN910
A	LEU923
A	PHE924
A	HIS926

---

site_id	AC3
Number of Residues	7
Details	binding site for residue FMT A 1103

Chain	Residue
A	ARG721
A	CYS794
A	GLN796
A	ASP797
A	GLY798
A	PRO799
A	LEU801

---

site_id	AC4
Number of Residues	5
Details	binding site for residue FMT A 1104

Chain	Residue
A	TYR806
A	ALA807
A	LYS808
A	ALA883
A	GLU884

---

site_id	AC5
Number of Residues	5
Details	binding site for residue FMT A 1105

Chain	Residue
A	SER703
A	LYS740
A	THR754
A	PHE924
A	HOH1240

---

site_id	AC6
Number of Residues	3
Details	binding site for residue FMT A 1106

Chain	Residue
A	HIS786
A	TRP856
A	LYS887

---

site_id	AC7
Number of Residues	4
Details	binding site for residue FMT A 1107

Chain	Residue
A	THR946
A	LEU947
A	GLY948
A	GLY949

---

site_id	AC8
Number of Residues	8
Details	binding site for residue FMT A 1108

Chain	Residue
A	PRO766
A	GLN910
A	GLY911
A	MET918
A	SER922
A	HIS926
A	TYR928
A	HOH1243

---

site_id	AC9
Number of Residues	5
Details	binding site for residue FMT A 1109

Chain	Residue
A	LYS728
A	LEU730
A	LYS740
A	TYR806
A	HOH1201

---

site_id	AD1
Number of Residues	3
Details	binding site for residue FMT A 1110

Chain	Residue
A	LEU746
A	ARG749
A	THR753

---

site_id	AD2
Number of Residues	4
Details	binding site for residue FMT A 1111

Chain	Residue
A	ARG770
A	SER774
A	ASN777
A	HOH1213

---

site_id	AD3
Number of Residues	2
Details	binding site for residue FMT A 1112

Chain	Residue
A	HIS784
A	GLN860

---

site_id	AD4
Number of Residues	2
Details	binding site for residue FMT A 1113

Chain	Residue
A	PHE924
A	ASP925

---

site_id	AD5
Number of Residues	9
Details	binding site for residue FMT A 1114

Chain	Residue
A	ARG873
A	ASP874
A	LEU875
A	ALA876
A	ARG878
A	ILE913
A	PRO914
A	TRP917
A	SER936

---

site_id	AD6
Number of Residues	6
Details	binding site for residue FMT A 1115

Chain	Residue
A	ARG873
A	LEU895
A	ARG897
A	LYS907
A	GLY911
A	ARG912

---

site_id	AD7
Number of Residues	5
Details	binding site for residue FMT A 1116

Chain	Residue
A	ARG969
A	TRP988
A	LYS989
A	GLN990
A	HOH1239

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	29
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGEFGKVVkAtafhlkgragytt.....VAVK

Chain	Residue	Details
A	LEU730-LYS758

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. LVHrDLAARNILV

Chain	Residue	Details
A	LEU870-VAL882

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	ASP874

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000305|PubMed:24560924, ECO:0007744|PDB:4CKI

Chain	Residue	Details
A	LEU730

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000305|PubMed:24560924

Chain	Residue	Details
A	LYS758

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:20117004, ECO:0007744|PDB:2X2M

Chain	Residue	Details
A	GLU805

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Cleavage; by caspase-3 => ECO:0000269|PubMed:21357690

Chain	Residue	Details
A	ASP707

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	SITE: Breakpoint for translocation to form PCM1-RET; RET-CCDC6; RET-GOLGA5; RET-TRIM24 and RET-TRIM33 oncogenes => ECO:0000269|PubMed:10439047, ECO:0000269|PubMed:10980597, ECO:0000269|PubMed:2406025, ECO:0000269|PubMed:2734021

Chain	Residue	Details
A	LEU712

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:14711813

Chain	Residue	Details
A	TYR806
A	TYR809

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:24560924

Chain	Residue	Details
A	TYR826

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:14711813, ECO:0000269|PubMed:16928683, ECO:0000269|PubMed:24560924

Chain	Residue	Details
A	TYR900

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:14711813, ECO:0000269|PubMed:16928683, ECO:0000269|PubMed:20117004, ECO:0000269|PubMed:24560924, ECO:0000269|PubMed:28846099

Chain	Residue	Details
A	PTR905

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:14711813, ECO:0000269|PubMed:24560924

Chain	Residue	Details
A	TYR981

---