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6I5J

Crystal structure of SOCS2:Elongin C:Elongin B in complex with growth hormone receptor peptide

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ASuppressor of cytokine signaling 2polymer16919481.21UniProt (O14508)
Pfam (PF00017)
Pfam (PF07525)
In PDB
Homo sapiens (Human)SOCS-2,Cytokine-inducible SH2 protein 2,CIS-2,STAT-induced STAT inhibitor 2,SSI-2
2B, EElongin-Bpolymer10411852.42UniProt (Q15370)
Pfam (PF00240)
In PDB
Homo sapiens (Human)EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
3C, FElongin-Cpolymer9710974.62UniProt (Q15369)
Pfam (PF03931)
In PDB
Homo sapiens (Human)EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1
4DSuppressor of cytokine signaling 2polymer16919377.31UniProt (O14508)
Pfam (PF00017)
Pfam (PF07525)
In PDB
Homo sapiens (Human)SOCS-2,Cytokine-inducible SH2 protein 2,CIS-2,STAT-induced STAT inhibitor 2,SSI-2
5I, J, K, LGrowth hormone receptor peptidepolymer111320.44Homo sapiens
6A, DCOBALT (II) IONnon-polymer58.92Chemie (CO)
7waterwater18.033Chemie (HOH)
Sequence modifications
A: 30 - 198 (UniProt: O14508)
PDBExternal DatabaseDetails
Met 31Pro 31engineered mutation
C, F: 17 - 112 (UniProt: Q15369)
PDBExternal DatabaseDetails
Met 16-initiating methionine
D: 30 - 198 (UniProt: O14508)
PDBExternal DatabaseDetails
Met 31Pro 31engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains10
Total formula weight89794.1
Non-Polymers*Number of molecules2
Total formula weight117.9
All*Total formula weight89912.0
*Water molecules are not included.

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PDB entries from 2024-06-12

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