6I5J
Crystal structure of SOCS2:Elongin C:Elongin B in complex with growth hormone receptor peptide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Suppressor of cytokine signaling 2 | polymer | 169 | 19481.2 | 1 | UniProt (O14508) Pfam (PF00017) Pfam (PF07525) In PDB | Homo sapiens (Human) | SOCS-2,Cytokine-inducible SH2 protein 2,CIS-2,STAT-induced STAT inhibitor 2,SSI-2 |
2 | B, E | Elongin-B | polymer | 104 | 11852.4 | 2 | UniProt (Q15370) Pfam (PF00240) In PDB | Homo sapiens (Human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
3 | C, F | Elongin-C | polymer | 97 | 10974.6 | 2 | UniProt (Q15369) Pfam (PF03931) In PDB | Homo sapiens (Human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
4 | D | Suppressor of cytokine signaling 2 | polymer | 169 | 19377.3 | 1 | UniProt (O14508) Pfam (PF00017) Pfam (PF07525) In PDB | Homo sapiens (Human) | SOCS-2,Cytokine-inducible SH2 protein 2,CIS-2,STAT-induced STAT inhibitor 2,SSI-2 |
5 | I, J, K, L | Growth hormone receptor peptide | polymer | 11 | 1320.4 | 4 | Homo sapiens | ||
6 | A, D | COBALT (II) ION | non-polymer | 58.9 | 2 | Chemie (CO) | |||
7 | water | water | 18.0 | 33 | Chemie (HOH) |
Sequence modifications
A: 30 - 198 (UniProt: O14508)
C, F: 17 - 112 (UniProt: Q15369)
D: 30 - 198 (UniProt: O14508)
PDB | External Database | Details |
---|---|---|
Met 31 | Pro 31 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met 16 | - | initiating methionine |
PDB | External Database | Details |
---|---|---|
Met 31 | Pro 31 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 10 |
Total formula weight | 89794.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 117.9 | |
All* | Total formula weight | 89912.0 |