6I5J

Crystal structure of SOCS2:Elongin C:Elongin B in complex with growth hormone receptor peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Suppressor of cytokine signaling 2	polymer	169	19481.2	1	UniProt (O14508) Pfam (PF00017) Pfam (PF07525)	Homo sapiens (Human)	SOCS-2,Cytokine-inducible SH2 protein 2,CIS-2,STAT-induced STAT inhibitor 2,SSI-2
2	B, E (B, E)	Elongin-B	polymer	104	11852.4	2	UniProt (Q15370) Pfam (PF00240)	Homo sapiens (Human)	EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
3	C, F (C, F)	Elongin-C	polymer	97	10974.6	2	UniProt (Q15369) Pfam (PF03931)	Homo sapiens (Human)	EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1
4	D (D)	Suppressor of cytokine signaling 2	polymer	169	19377.3	1	UniProt (O14508) Pfam (PF00017) Pfam (PF07525)	Homo sapiens (Human)	SOCS-2,Cytokine-inducible SH2 protein 2,CIS-2,STAT-induced STAT inhibitor 2,SSI-2
5	G, H, I, J (I, J, K, L)	Growth hormone receptor peptide	polymer	11	1320.4	4		Homo sapiens
6	K, L (A, D)	COBALT (II) ION	non-polymer		58.9	2	Chemie (CO)
7	M, N, O, P, Q... (A, B, C, D, E...)	water	water		18.0	33	Chemie (HOH)

Sequence modifications

A: 30 - 198 (UniProt: O14508)

PDB	External Database	Details
Met 31	Pro 31	engineered mutation

C, F: 17 - 112 (UniProt: Q15369)

PDB	External Database	Details
Met 16	-	initiating methionine

D: 30 - 198 (UniProt: O14508)

PDB	External Database	Details
Met 31	Pro 31	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	89794.1
Non-Polymers*	Number of molecules	2
	Total formula weight	117.9
All*	Total formula weight	89912.0

*Water molecules are not included.