6I5J

Crystal structure of SOCS2:Elongin C:Elongin B in complex with growth hormone receptor peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0035556	biological_process	intracellular signal transduction
B	0006368	biological_process	transcription elongation by RNA polymerase II
B	0030891	cellular_component	VCB complex
B	0070449	cellular_component	elongin complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0035556	biological_process	intracellular signal transduction
E	0006368	biological_process	transcription elongation by RNA polymerase II
E	0030891	cellular_component	VCB complex
E	0070449	cellular_component	elongin complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CO A 201

Chain	Residue
A	HIS149
A	HOH301
K	HIS4
K	HOH103

---

site_id	AC2
Number of Residues	2
Details	binding site for residue CO D 201

Chain	Residue
D	HIS149
L	HIS4

---

site_id	AC3
Number of Residues	12
Details	binding site for Di-peptide PTR I 0 and THR I 1

Chain	Residue
A	THR83
A	THR93
A	ASN94
A	LEU95
A	ARG96
I	ASP-1
I	PRO-2
I	SER2
K	VLM6
A	ARG73
A	SER75
A	SER76

---

site_id	AC4
Number of Residues	3
Details	binding site for Di-peptide ILE I 5 and VLM I 6

Chain	Residue
I	HIS4
K	THR1
K	SER2

---

site_id	AC5
Number of Residues	9
Details	binding site for Di-peptide ASP I -1 and PTR I 0

Chain	Residue
A	ARG73
A	SER75
A	SER76
A	THR83
A	THR93
A	ASN94
A	ARG96
I	PRO-2
I	THR1

---

site_id	AC6
Number of Residues	11
Details	binding site for Di-peptide PTR J 0 and THR J 1

Chain	Residue
D	ARG73
D	SER75
D	SER76
D	THR83
D	ASN94
D	LEU95
D	ARG96
J	ASP-1
J	PRO-2
J	SER2
L	VLM6

---

site_id	AC7
Number of Residues	11
Details	binding site for Di-peptide ASP J -1 and PTR J 0

Chain	Residue
D	VAL55
D	ARG73
D	SER75
D	SER76
D	THR83
D	THR93
D	ASN94
D	ARG96
J	VAL-3
J	PRO-2
J	THR1

---

site_id	AC8
Number of Residues	11
Details	binding site for Di-peptide PTR K 0 and THR K 1

Chain	Residue
A	MET132
A	CAS133
A	ARG137
A	HIS149
I	ILE5
K	PRO-2
K	ASP-1
K	SER2
K	ILE3
K	HOH101
K	HOH102

---

site_id	AC9
Number of Residues	6
Details	binding site for Di-peptide ILE K 5 and VLM K 6

Chain	Residue
A	THR88
A	ILE109
A	VAL148
I	THR1
I	SER2
K	HIS4

---

site_id	AD1
Number of Residues	10
Details	binding site for Di-peptide ASP K -1 and PTR K 0

Chain	Residue
A	MET132
A	ARG137
A	HIS149
E	LYS36
K	PRO-2
K	VAL-3
K	THR1
K	SER2
K	HOH101
K	HOH102

---

site_id	AD2
Number of Residues	8
Details	binding site for Di-peptide PTR L 0 and THR L 1

Chain	Residue
D	MET132
D	CAS133
D	LYS136
D	ARG137
L	ASP-1
L	PRO-2
L	SER2
L	ILE3

---

site_id	AD3
Number of Residues	5
Details	binding site for Di-peptide ILE L 5 and VLM L 6

Chain	Residue
D	VAL148
J	THR1
J	SER2
J	ILE3
L	HIS4

---

site_id	AD4
Number of Residues	7
Details	binding site for Di-peptide ASP L -1 and PTR L 0

Chain	Residue
D	MET132
D	CAS133
D	LYS136
D	ARG137
L	PRO-2
L	THR1
L	SER2

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
D	SER30
E	MET1

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:31578312

Chain	Residue	Details
D	SER52
E	THR84

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:31578312

Chain	Residue	Details
D	LYS173

---