6I5I
Crystal structure of CLK1 in complexed with furo[3,2-b]pyridine compound 12h
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dual specificity protein kinase CLK1 | polymer | 339 | 39581.5 | 1 | UniProt (P49759) Pfam (PF00069) | Homo sapiens (Human) | CDC-like kinase 1 |
| 2 | B (A) | 5-(1-methylpyrazol-4-yl)-3-[1-(phenylmethyl)pyrazol-4-yl]furo[3,2-b]pyridine | non-polymer | 355.4 | 1 | Chemie (H3E) | |||
| 3 | C, D, E, F, G... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 12 | Chemie (EDO) | |||
| 4 | O (A) | water | water | 18.0 | 369 | Chemie (HOH) |
Sequence modifications
A: 148 - 484 (UniProt: P49759)
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Met 0 | - | expression tag |
| Ala 432 | Arg 432 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39581.5 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1100.2 | |
| All* | Total formula weight | 40681.7 |
