6I4B
Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) co-crystallized with 3-Hydroxy-1-methyl-5-((3-(trifluoromethyl)phenoxy)methyl)-1H-pyrazole-4-carboxylic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Dihydroorotate dehydrogenase | polymer | 405 | 45852.5 | 2 | UniProt (Q54A96) Pfam (PF01180) UniProt (by SIFTS) (Q08210) In PDB | Plasmodium falciparum (malaria parasite P. falciparum) | |
| 2 | A, B | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 2 | Chemie (FMN) | |||
| 3 | A, B | OROTIC ACID | non-polymer | 156.1 | 2 | Chemie (ORO) | |||
| 4 | A, B | 1-methyl-3-oxidanyl-5-[[3-(trifluoromethyl)phenoxy]methyl]pyrazole-4-carboxylic acid | non-polymer | 316.2 | 2 | Chemie (E2N) | |||
| 5 | water | water | 18.0 | 292 | Chemie (HOH) |
Sequence modifications
A, B: 158 - 569 (UniProt: Q54A96)
| PDB | External Database | Details |
|---|---|---|
| Met 135 | - | initiating methionine |
| His 136 | - | expression tag |
| His 137 | - | expression tag |
| His 138 | - | expression tag |
| His 139 | - | expression tag |
| His 140 | - | expression tag |
| His 141 | - | expression tag |
| Ser 142 | - | expression tag |
| Ser 143 | - | expression tag |
| Gly 144 | - | expression tag |
| Val 145 | - | expression tag |
| Asp 146 | - | expression tag |
| Leu 147 | - | expression tag |
| Gly 148 | - | expression tag |
| Thr 149 | - | expression tag |
| Glu 150 | - | expression tag |
| Asn 151 | - | expression tag |
| Leu 152 | - | expression tag |
| Tyr 153 | - | expression tag |
| Phe 154 | - | expression tag |
| Gln 155 | - | expression tag |
| Ser 156 | - | expression tag |
| Met 157 | - | expression tag |
| - | Ser 384 | deletion |
| - | Thr 385 | deletion |
| - | Tyr 386 | deletion |
| - | Asn 387 | deletion |
| - | Glu 388 | deletion |
| - | Asp 389 | deletion |
| - | Asn 390 | deletion |
| - | Lys 391 | deletion |
| - | Ile 392 | deletion |
| - | Val 393 | deletion |
| - | Glu 394 | deletion |
| - | Lys 395 | deletion |
| - | Lys 396 | deletion |
| - | Asn 397 | deletion |
| - | Asn 398 | deletion |
| - | Phe 399 | deletion |
| - | Asn 400 | deletion |
| - | Lys 401 | deletion |
| - | Asn 402 | deletion |
| - | Asn 403 | deletion |
| - | Ser 404 | deletion |
| - | His 405 | deletion |
| - | Met 406 | deletion |
| - | Met 407 | deletion |
| - | Lys 408 | deletion |
| - | Asp 409 | deletion |
| - | Ala 410 | deletion |
| - | Lys 411 | deletion |
| - | Asp 412 | deletion |
| - | Asn 413 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 91704.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1857.3 | |
| All* | Total formula weight | 93562.3 |
