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6I2H

Crystal Structure of the Protein-Kinase A catalytic subunit from Cricetulus Griseus in complex with compounds RKp182 and RKp190

Replaces:  6EME
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
cAMP-dependent protein kinase catalytic subunit alphapolymer35341193.71UniProt (P25321)
Pfam (PF00069)
Cricetulus griseus (Chinese hamster)PKA C-alpha
2B
(D)
UPF0418 protein FAM164Apolymer182004.21UniProt (G3HK48)Cricetulus griseus
3C
(A)
[2-[[2-(isoquinolin-5-ylsulfonylamino)ethylamino]methyl]phenyl]boronic acidnon-polymer385.21Chemie (AO8)
4D
(D)
beta-D-ribopyranosenon-polymer150.11Chemie (RIP)
5E
(D)
CHLORIDE IONnon-polymer35.51Chemie (CL)
6F, G
(A, D)
waterwater18.0196Chemie (HOH)
Sequence modifications
A: 0 - 350 (UniProt: P25321)
PDBExternal DatabaseDetails
Gly -2-expression tag
His -1-expression tag
D: 8 - 25 (UniProt: G3HK48)
PDBExternal DatabaseDetails
Ser 20Gly 18conflict
Asp 23Asn 21conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight43197.9
Non-Polymers*Number of molecules3
Total formula weight570.8
All*Total formula weight43768.8
*Water molecules are not included.

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