6I2H

Crystal Structure of the Protein-Kinase A catalytic subunit from Cricetulus Griseus in complex with compounds RKp182 and RKp190

Replaces:  6EME

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	cAMP-dependent protein kinase catalytic subunit alpha	polymer	353	41193.7	1	UniProt (P25321) Pfam (PF00069) In PDB	Cricetulus griseus (Chinese hamster)	PKA C-alpha
2	D	UPF0418 protein FAM164A	polymer	18	2004.2	1	UniProt (G3HK48) In PDB	Cricetulus griseus
3	A	[2-[[2-(isoquinolin-5-ylsulfonylamino)ethylamino]methyl]phenyl]boronic acid	non-polymer		385.2	1	Chemie (AO8)
4	D	beta-D-ribopyranose	non-polymer		150.1	1	Chemie (RIP)
5	D	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
6		water	water		18.0	196	Chemie (HOH)

Sequence modifications

A: 0 - 350 (UniProt: P25321)

PDB	External Database	Details
Gly -2	-	expression tag
His -1	-	expression tag

D: 8 - 25 (UniProt: G3HK48)

PDB	External Database	Details
Ser 20	Gly 18	conflict
Asp 23	Asn 21	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	43197.9
Non-Polymers*	Number of molecules	3
	Total formula weight	570.8
All*	Total formula weight	43768.8

*Water molecules are not included.