6HMD

STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA'; CSNK2A2 gene product) IN COMPLEX WITH THE INDENOINDOLE-TYPE INHIBITOR AR18

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Casein kinase II subunit alpha'	polymer	365	43018.0	1	UniProt (P19784) Pfam (PF00069)	Homo sapiens (Human)	CK II alpha'
2	B, C (A)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
3	D (A)	5-[2-(diethylamino)ethyl]-7,8-dihydro-6~{H}-indeno[1,2-b]indole-9,10-dione	non-polymer		336.4	1	Chemie (GDW)
4	E (A)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
5	F (A)	water	water		18.0	482	Chemie (HOH)

Sequence modifications

A: 1 - 350 (UniProt: P19784)

PDB	External Database	Details
His -14	-	expression tag
Met -13	-	expression tag
Gly -12	-	expression tag
Ser -11	-	expression tag
Ser -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Ser -3	-	expression tag
Gln -2	-	expression tag
Asp -1	-	expression tag
Pro 0	-	expression tag
Ser 336	Cys 336	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	43018.0
Non-Polymers*	Number of molecules	4
	Total formula weight	496.0
All*	Total formula weight	43514.0

*Water molecules are not included.