6HMC
STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA'; CSNK2A2 gene product) IN COMPLEX WITH THE INDENOINDOLE-TYPE INHIBITOR THN27
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Casein kinase II subunit alpha' | polymer | 364 | 42879.9 | 1 | UniProt (P19784) Pfam (PF00069) In PDB | Homo sapiens (Human) | CK II alpha' |
2 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 8 | Chemie (EDO) | |||
3 | A | 5-propan-2-yl-4-prop-2-enoxy-7,8-dihydro-6~{H}-indeno[1,2-b]indole-9,10-dione | non-polymer | 335.4 | 1 | Chemie (FXB) | |||
4 | water | water | 18.0 | 433 | Chemie (HOH) |
Sequence modifications
A: 1 - 350 (UniProt: P19784)
PDB | External Database | Details |
---|---|---|
Met -13 | - | initiating methionine |
Gly -12 | - | expression tag |
Ser -11 | - | expression tag |
Ser -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
Ser -3 | - | expression tag |
Gln -2 | - | expression tag |
Asp -1 | - | expression tag |
Pro 0 | - | expression tag |
Ser 336 | Cys 336 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 42879.9 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 831.9 | |
All* | Total formula weight | 43711.8 |