6HMC
STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA'; CSNK2A2 gene product) IN COMPLEX WITH THE INDENOINDOLE-TYPE INHIBITOR THN27
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000785 | cellular_component | chromatin |
| A | 0001669 | cellular_component | acrosomal vesicle |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005956 | cellular_component | protein kinase CK2 complex |
| A | 0006302 | biological_process | double-strand break repair |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0006915 | biological_process | apoptotic process |
| A | 0007049 | biological_process | cell cycle |
| A | 0007283 | biological_process | spermatogenesis |
| A | 0016055 | biological_process | Wnt signaling pathway |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016310 | biological_process | phosphorylation |
| A | 0016740 | molecular_function | transferase activity |
| A | 0018105 | biological_process | peptidyl-serine phosphorylation |
| A | 0021987 | biological_process | cerebral cortex development |
| A | 0031519 | cellular_component | PcG protein complex |
| A | 0051726 | biological_process | regulation of cell cycle |
| A | 0097421 | biological_process | liver regeneration |
| A | 0106310 | molecular_function | protein serine kinase activity |
| A | 1901524 | biological_process | regulation of mitophagy |
| A | 1903955 | biological_process | positive regulation of protein targeting to mitochondrion |
| A | 1905818 | biological_process | regulation of chromosome separation |
| A | 2000059 | biological_process | negative regulation of ubiquitin-dependent protein catabolic process |
| A | 2001234 | biological_process | negative regulation of apoptotic signaling pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 401 |
| Chain | Residue |
| A | HIS184 |
| A | HOH502 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 402 |
| Chain | Residue |
| A | ASP131 |
| A | HIS292 |
| A | VAL294 |
| A | HOH851 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 403 |
| Chain | Residue |
| A | ASP300 |
| A | HIS322 |
| A | HOH642 |
| A | HOH682 |
| A | LYS45 |
| A | PRO296 |
| A | GLU297 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 404 |
| Chain | Residue |
| A | GLU188 |
| A | ASN190 |
| A | GLN208 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 405 |
| Chain | Residue |
| A | LEU42 |
| A | PHE55 |
| A | GLU318 |
| A | GLU321 |
| A | HIS322 |
| A | HOH511 |
| A | HOH527 |
| A | HOH547 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue EDO A 406 |
| Chain | Residue |
| A | GLU64 |
| A | ARG65 |
| A | ASP206 |
| A | ASP265 |
| A | HOH506 |
| A | HOH532 |
| A | HOH536 |
| A | HOH650 |
| A | HOH919 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for residue EDO A 407 |
| Chain | Residue |
| A | TYR13 |
| A | VAL16 |
| A | VAL106 |
| A | HOH728 |
| A | HOH744 |
| A | HOH764 |
| A | HOH770 |
| A | HOH779 |
| A | HOH896 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 408 |
| Chain | Residue |
| A | ARG22 |
| A | GLN237 |
| site_id | AC9 |
| Number of Residues | 17 |
| Details | binding site for residue FXB A 409 |
| Chain | Residue |
| A | LEU46 |
| A | VAL54 |
| A | VAL67 |
| A | LYS69 |
| A | ILE96 |
| A | PHE114 |
| A | GLU115 |
| A | ILE117 |
| A | MET164 |
| A | ILE175 |
| A | ASP176 |
| A | HOH514 |
| A | HOH531 |
| A | HOH657 |
| A | HOH722 |
| A | HOH819 |
| A | HOH932 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnner..........VVVK |
| Chain | Residue | Details |
| A | LEU46-LYS69 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI |
| Chain | Residue | Details |
| A | ILE153-ILE165 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 |
| Chain | Residue | Details |
| A | ASP157 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | LEU46 | |
| A | LYS69 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19369195 |
| Chain | Residue | Details |
| A | TYR13 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER18 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195 |
| Chain | Residue | Details |
| A | SER21 | |
| A | SER288 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS97 |
