6HH1
Structure of c-Kit with allosteric inhibitor 3G8
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Mast/stem cell growth factor receptor Kit,Mast/stem cell growth factor receptor Kit | polymer | 303 | 34215.8 | 1 | UniProt (P10721) Pfam (PF07714) In PDB | Homo sapiens (Human) | SCFR,Piebald trait protein,PBT,Proto-oncogene c-Kit,Tyrosine-protein kinase Kit,p145 c-kit,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog,SCFR,Piebald trait protein,PBT,Proto-oncogene c-Kit,Tyrosine-protein kinase Kit,p145 c-kit,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
2 | A | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
3 | A | ~{N}-(2,3-dimethylphenyl)-5-(4-pyridin-4-yloxyphenyl)-4~{H}-1,2,4-triazol-3-amine | non-polymer | 357.4 | 1 | Chemie (G4E) | |||
4 | water | water | 18.0 | 122 | Chemie (HOH) |
Sequence modifications
A: 565 - 764 (UniProt: P10721)
A: 802 - 929 (UniProt: P10721)
PDB | External Database | Details |
---|---|---|
Thr 694 | Gln 690 | conflict |
Ser 753 | Glu 691 | conflict |
Pro 754 | Asp 692 | conflict |
Ala 755 | His 693 | conflict |
Ile 756 | Ala 694 | conflict |
Leu 762 | Ala 696 | conflict |
PDB | External Database | Details |
---|---|---|
Asp 765 | - | linker |
Leu 766 | - | linker |
Glu 767 | - | linker |
Asp 768 | - | linker |
Leu 769 | - | linker |
Leu 770 | - | linker |
Ser 771 | - | linker |
Phe 772 | - | linker |
Ser 773 | - | linker |
Tyr 774 | - | linker |
Gln 775 | - | linker |
Val 776 | - | linker |
Ala 777 | - | linker |
Lys 778 | - | linker |
Gly 779 | - | linker |
Met 780 | - | linker |
Ala 781 | - | linker |
Phe 782 | - | linker |
Leu 783 | - | linker |
Ala 784 | - | linker |
Ser 785 | - | linker |
Lys 786 | - | linker |
Asn 787 | - | linker |
Cys 788 | - | linker |
Ile 789 | - | linker |
His 790 | - | linker |
Arg 791 | - | linker |
Asp 792 | - | linker |
Leu 793 | - | linker |
Ala 794 | - | linker |
Ala 795 | - | linker |
Arg 796 | - | linker |
Asn 797 | - | linker |
Ile 798 | - | linker |
Leu 799 | - | linker |
Leu 800 | - | linker |
Thr 801 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 34215.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 452.4 | |
All* | Total formula weight | 34668.1 |