6HH1
Structure of c-Kit with allosteric inhibitor 3G8
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mast/stem cell growth factor receptor Kit,Mast/stem cell growth factor receptor Kit | polymer | 303 | 34215.8 | 1 | UniProt (P10721) Pfam (PF07714) | Homo sapiens (Human) | SCFR,Piebald trait protein,PBT,Proto-oncogene c-Kit,Tyrosine-protein kinase Kit,p145 c-kit,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog,SCFR,Piebald trait protein,PBT,Proto-oncogene c-Kit,Tyrosine-protein kinase Kit,p145 c-kit,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
| 2 | B (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 3 | C (A) | ~{N}-(2,3-dimethylphenyl)-5-(4-pyridin-4-yloxyphenyl)-4~{H}-1,2,4-triazol-3-amine | non-polymer | 357.4 | 1 | Chemie (G4E) | |||
| 4 | D (A) | water | water | 18.0 | 122 | Chemie (HOH) |
Sequence modifications
A: 565 - 764 (UniProt: P10721)
A: 802 - 929 (UniProt: P10721)
| PDB | External Database | Details |
|---|---|---|
| Thr 694 | Gln 690 | conflict |
| Ser 753 | Glu 691 | conflict |
| Pro 754 | Asp 692 | conflict |
| Ala 755 | His 693 | conflict |
| Ile 756 | Ala 694 | conflict |
| Leu 762 | Ala 696 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Asp 765 | - | linker |
| Leu 766 | - | linker |
| Glu 767 | - | linker |
| Asp 768 | - | linker |
| Leu 769 | - | linker |
| Leu 770 | - | linker |
| Ser 771 | - | linker |
| Phe 772 | - | linker |
| Ser 773 | - | linker |
| Tyr 774 | - | linker |
| Gln 775 | - | linker |
| Val 776 | - | linker |
| Ala 777 | - | linker |
| Lys 778 | - | linker |
| Gly 779 | - | linker |
| Met 780 | - | linker |
| Ala 781 | - | linker |
| Phe 782 | - | linker |
| Leu 783 | - | linker |
| Ala 784 | - | linker |
| Ser 785 | - | linker |
| Lys 786 | - | linker |
| Asn 787 | - | linker |
| Cys 788 | - | linker |
| Ile 789 | - | linker |
| His 790 | - | linker |
| Arg 791 | - | linker |
| Asp 792 | - | linker |
| Leu 793 | - | linker |
| Ala 794 | - | linker |
| Ala 795 | - | linker |
| Arg 796 | - | linker |
| Asn 797 | - | linker |
| Ile 798 | - | linker |
| Leu 799 | - | linker |
| Leu 800 | - | linker |
| Thr 801 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34215.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 452.4 | |
| All* | Total formula weight | 34668.1 |
