6HCH

STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-L504Y-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM01 AT 1.6 A RESOLUTION.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Glutamate receptor 2	polymer	264	29301.7	3	UniProt (P19491) Pfam (PF10613) Pfam (PF00060) In PDB	Rattus norvegicus (Rat)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2,GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2
2	C, A, B	GLUTAMIC ACID	non-polymer		147.1	3	Chemie (GLU)
3	C, A, B	ZINC ION	non-polymer		65.4	23	Chemie (ZN)
4	C, A	6,6'-(Ethane-1,2-diyl)bis(4-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide)	non-polymer		422.5	2	Chemie (D45)
5	B, C, A	ACETATE ION	non-polymer		59.0	8	Chemie (ACT)
6	A, C	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
7	B, C	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL)
8	C	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
9		water	water		18.0	802	Chemie (HOH)

Sequence modifications

A, B, C: 3 - 117 (UniProt: P19491)

PDB	External Database	Details
Gly 1	-	expression tag
Ala 2	-	expression tag
Tyr 94	Leu 504	engineered mutation

A, B, C: 120 - 264 (UniProt: P19491)

PDB	External Database	Details
Gly 118	-	linker
Thr 119	-	linker
Ser 242	Asn 775	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	87905.2
Non-Polymers*	Number of molecules	42
	Total formula weight	3649.8
All*	Total formula weight	91555.0

*Water molecules are not included.