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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6HCH

STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-L504Y-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM01 AT 1.6 A RESOLUTION.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue GLU A 301

Chain	Residue
A	TYR61
A	TYR220
A	HOH429
A	HOH439
A	HOH505
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	GLY141
A	SER142
A	THR143
A	GLU193

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 302

Chain	Residue
A	HIS23
A	ACT313
B	ASP65
B	HOH475

site_id	AC3
Number of Residues	3
Details	binding site for residue ZN A 303

Chain	Residue
A	HOH405
A	HOH415
A	HOH606

site_id	AC4
Number of Residues	1
Details	binding site for residue ZN A 304

Chain	Residue
A	HOH444

site_id	AC5
Number of Residues	3
Details	binding site for residue ZN A 305

Chain	Residue
A	ASP156
A	HOH435
B	MET25

site_id	AC6
Number of Residues	2
Details	binding site for residue ZN A 306

Chain	Residue
A	GLU24
A	HOH625

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN A 307

Chain	Residue
A	THR9
A	THR54
A	GLU77
A	HOH457

site_id	AC8
Number of Residues	5
Details	binding site for residue ZN A 308

Chain	Residue
A	HOH628
A	HOH658
A	HOH660
A	HOH666
A	HOH677

site_id	AC9
Number of Residues	2
Details	binding site for residue ZN A 309

Chain	Residue
A	GLU132
A	HOH595

site_id	AD1
Number of Residues	2
Details	binding site for residue ZN A 310

Chain	Residue
A	ASP126
A	HOH414

site_id	AD2
Number of Residues	14
Details	binding site for residue D45 A 311

Chain	Residue
A	LYS104
A	PRO105
A	SER108
A	SER217
A	LYS218
A	GLY219
A	SER242
B	LYS104
B	PRO105
B	SER108
B	SER217
B	LYS218
B	GLY219
B	SER242

site_id	AD3
Number of Residues	5
Details	binding site for residue ACT A 312

Chain	Residue
A	ARG180
A	SER184
A	LYS187
A	TYR188
A	HOH463

site_id	AD4
Number of Residues	7
Details	binding site for residue ACT A 313

Chain	Residue
A	MET19
A	HIS23
A	ZN302
B	ASP65
B	ASP67
B	THR68
B	HOH475

site_id	AD5
Number of Residues	5
Details	binding site for residue GOL A 314

Chain	Residue
A	ASN214
A	ASP216
A	SER217
A	HOH467
B	ASP248

site_id	AD6
Number of Residues	4
Details	binding site for residue ZN A 315

Chain	Residue
A	GLU42
A	HIS46
A	ACT316
C	GLU166

site_id	AD7
Number of Residues	8
Details	binding site for residue ACT A 316

Chain	Residue
A	GLU42
A	LYS45
A	HIS46
A	ZN315
C	ARG163
C	ALA165
C	GLU166
C	SER168

site_id	AD8
Number of Residues	13
Details	binding site for residue GLU B 301

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	LEU138
B	GLY141
B	SER142
B	THR143
B	GLU193
B	HOH434
B	HOH443
B	HOH460

site_id	AD9
Number of Residues	3
Details	binding site for residue ZN B 302

Chain	Residue
B	GLU42
B	LYS45
B	HIS46

site_id	AE1
Number of Residues	3
Details	binding site for residue ZN B 303

Chain	Residue
B	ACT307
B	HOH474
B	ASP156

site_id	AE2
Number of Residues	2
Details	binding site for residue ZN B 304

Chain	Residue
B	HOH411
B	HOH478

site_id	AE3
Number of Residues	1
Details	binding site for residue ZN B 305

Chain	Residue
B	HOH408

site_id	AE4
Number of Residues	4
Details	binding site for residue ZN B 306

Chain	Residue
B	HOH603
B	HOH611
B	HOH618
B	HOH620

site_id	AE5
Number of Residues	4
Details	binding site for residue ACT B 307

Chain	Residue
B	ARG148
B	ASP156
B	ZN303
B	HOH426

site_id	AE6
Number of Residues	4
Details	binding site for residue ACT B 308

Chain	Residue
B	ARG180
B	SER184
B	LYS187
B	TYR188

site_id	AE7
Number of Residues	2
Details	binding site for residue CL B 309

Chain	Residue
B	LYS4
B	THR5

site_id	AE8
Number of Residues	13
Details	binding site for residue GLU C 301

Chain	Residue
C	TYR61
C	PRO89
C	LEU90
C	THR91
C	ARG96
C	LEU138
C	GLY141
C	SER142
C	THR143
C	GLU193
C	HOH455
C	HOH480
C	HOH501

site_id	AE9
Number of Residues	4
Details	binding site for residue ZN C 302

Chain	Residue
A	GLU166
C	GLU42
C	HIS46
C	HOH412

site_id	AF1
Number of Residues	4
Details	binding site for residue ZN C 303

Chain	Residue
B	HIS23
C	HIS23
C	GLU30
C	ACT311

site_id	AF2
Number of Residues	4
Details	binding site for residue ZN C 304

Chain	Residue
C	ASP156
C	HOH426
C	HOH584
C	HOH640

site_id	AF3
Number of Residues	3
Details	binding site for residue ZN C 305

Chain	Residue
C	HOH401
C	HOH405
C	HOH639

site_id	AF4
Number of Residues	2
Details	binding site for residue ZN C 306

Chain	Residue
C	HOH441
C	HOH563

site_id	AF5
Number of Residues	3
Details	binding site for residue ZN C 307

Chain	Residue
C	ASP126
C	HOH521
C	HOH673

site_id	AF6
Number of Residues	1
Details	binding site for residue ZN C 308

Chain	Residue
C	GLU132

site_id	AF7
Number of Residues	3
Details	binding site for residue ZN C 309

Chain	Residue
C	HOH700
C	HOH703
C	HOH704

site_id	AF8
Number of Residues	14
Details	binding site for residue D45 C 310

Chain	Residue
C	LYS104
C	LYS104
C	PRO105
C	PRO105
C	SER108
C	SER108
C	SER217
C	SER217
C	LYS218
C	LYS218
C	GLY219
C	GLY219
C	SER242
C	SER242

site_id	AF9
Number of Residues	6
Details	binding site for residue ACT C 311

Chain	Residue
B	HIS23
B	GLU24
C	LYS20
C	HIS23
C	GLU30
C	ZN303

site_id	AG1
Number of Residues	3
Details	binding site for residue ACT C 312

Chain	Residue
C	ARG180
C	SER184
C	LYS187

site_id	AG2
Number of Residues	5
Details	binding site for residue ACT C 313

Chain	Residue
C	LYS117
C	GLU201
C	GLN202
C	CYS261
C	HOH467

site_id	AG3
Number of Residues	5
Details	binding site for residue SO4 C 314

Chain	Residue
C	SER140
C	LYS144
C	ARG148
C	HOH404
C	HOH413

site_id	AG4
Number of Residues	2
Details	binding site for residue CL C 315

Chain	Residue
C	LYS4
C	THR5

site_id	AG5
Number of Residues	1
Details	binding site for residue CL C 316

Chain	Residue
C	ALA153

site_id	AG6
Number of Residues	5
Details	binding site for residue GOL C 317

Chain	Residue
C	ASN214
C	ASP216
C	SER217
C	ASP248
C	HOH418

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269\|PubMed:11086992, ECO:0000269\|PubMed:16483599, ECO:0007744\|PDB:1FTJ, ECO:0007744\|PDB:2CMO

Chain	Residue	Details
A	PRO89
B	SER142
B	THR143
B	GLU193
C	PRO89
C	THR91
C	ARG96
C	SER142
C	THR143
C	GLU193
A	THR91
A	ARG96
A	SER142
A	THR143
A	GLU193
B	PRO89
B	THR91
B	ARG96

site_id	SWS_FT_FI2
Number of Residues	9
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269\|PubMed:25103405

Chain	Residue	Details
A	ARG64
A	ARG148
A	LYS240
B	ARG64
B	ARG148
B	LYS240
C	ARG64
C	ARG148
C	LYS240

site_id	SWS_FT_FI3
Number of Residues	3
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269\|PubMed:25103405

Chain	Residue	Details
A	ILE121
B	ILE121
C	ILE121

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269\|PubMed:8848293

Chain	Residue	Details
A	SER150
B	SER150
C	SER150

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269\|PubMed:8848293

Chain	Residue	Details
A	SER184
B	SER184
C	SER184

site_id	SWS_FT_FI6
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
B	ASN3
C	ASN3

223166

PDB entries from 2024-07-31

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