6HAW
Crystal structure of bovine cytochrome bc1 in complex with 2-pyrazolyl quinolone inhibitor WDH2G7
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cytochrome b-c1 complex subunit 1, mitochondrial | polymer | 438 | 48323.3 | 1 | UniProt (P31800) Pfam (PF00675) Pfam (PF05193) | Bos taurus (cattle) | Complex III subunit 1,Core protein I,Ubiquinol-cytochrome-c reductase complex core protein 1 |
| 2 | B (B) | Cytochrome b-c1 complex subunit 2, mitochondrial | polymer | 413 | 44067.5 | 1 | UniProt (P23004) Pfam (PF00675) Pfam (PF05193) | Bos taurus (cattle) | |
| 3 | C (C) | Cytochrome b | polymer | 378 | 42489.1 | 1 | UniProt (P00157) Pfam (PF00033) Pfam (PF00032) | Bos taurus (cattle) | Complex III subunit 3,Complex III subunit III,Cytochrome b-c1 complex subunit 3,Ubiquinol-cytochrome-c reductase complex cytochrome b subunit |
| 4 | D (D) | Cytochrome c1, heme protein, mitochondrial | polymer | 239 | 27107.0 | 1 | UniProt (P00125) Pfam (PF02167) | Bos taurus (cattle) | Complex III subunit 4,Complex III subunit IV,Cytochrome b-c1 complex subunit 4,Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit,Cytochrome c-1 |
| 5 | E (E) | Cytochrome b-c1 complex subunit Rieske, mitochondrial | polymer | 196 | 21640.6 | 1 | UniProt (P13272) Pfam (PF02921) Pfam (PF00355) | Bos taurus (cattle) | Complex III subunit 5,Cytochrome b-c1 complex subunit 5,Rieske iron-sulfur protein,RISP,Rieske protein UQCRFS1,Ubiquinol-cytochrome c reductase iron-sulfur subunit |
| 6 | F (F) | Cytochrome b-c1 complex subunit 7 | polymer | 99 | 12357.1 | 1 | UniProt (P00129) Pfam (PF02271) | Bos taurus (cattle) | Complex III subunit 7,Complex III subunit VII,QP-C,Ubiquinol-cytochrome c reductase complex 14 kDa protein |
| 7 | G (G) | Cytochrome b-c1 complex subunit 8 | polymer | 74 | 8799.2 | 1 | UniProt (P13271) Pfam (PF02939) | Bos taurus (cattle) | Complex III subunit 8,Complex III subunit VIII,Ubiquinol-cytochrome c reductase complex 9.5 kDa protein,Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C |
| 8 | H (H) | Cytochrome b-c1 complex subunit 6, mitochondrial | polymer | 64 | 7515.4 | 1 | UniProt (P00126) Pfam (PF02320) | Bos taurus (cattle) | Complex III subunit 6,Complex III subunit VIII,Cytochrome c1 non-heme 11 kDa protein,Mitochondrial hinge protein,Ubiquinol-cytochrome c reductase complex 11 kDa protein |
| 9 | I (I) | Cytochrome b-c1 complex subunit Rieske, mitochondrial | polymer | 46 | 4827.6 | 1 | UniProt (P13272) Pfam (PF09165) | Bos taurus (cattle) | Complex III subunit 5,Cytochrome b-c1 complex subunit 5,Rieske iron-sulfur protein,RISP,Rieske protein UQCRFS1,Ubiquinol-cytochrome c reductase iron-sulfur subunit |
| 10 | J (J) | Cytochrome b-c1 complex subunit 9 | polymer | 59 | 6866.9 | 1 | UniProt (P00130) Pfam (PF05365) | Bos taurus (cattle) | Complex III subunit 9,Complex III subunit X,Cytochrome c1 non-heme 7 kDa protein,Ubiquinol-cytochrome c reductase complex 7.2 kDa protein |
| 11 | K (A) | 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE | non-polymer | 410.4 | 1 | Chemie (6PE) | |||
| 12 | AA, BA, L, Z (C, A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 4 | Chemie (PGE) | |||
| 13 | EA, IA, LA, M, MA... (D, E, F, A, G...) | PHOSPHATE ION | non-polymer | 95.0 | 11 | Chemie (PO4) | |||
| 14 | FA, KA, P, W (D, E, A, C) | CARDIOLIPIN | non-polymer | 1464.0 | 4 | Chemie (CDL) | |||
| 15 | R (B) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 16 | CA, S (C, B) | 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE | non-polymer | 647.9 | 2 | Chemie (PX6) | |||
| 17 | T, U (C) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 18 | V (C) | DODECYL-BETA-D-MALTOSIDE | non-polymer | 510.6 | 1 | Chemie (LMT) | |||
| 19 | JA, X (E, C) | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine | non-polymer | 744.0 | 2 | Chemie (PEE) | |||
| 20 | Y (C) | 7-methoxy-3-methyl-2-[1-[[4-(trifluoromethyloxy)phenyl]methyl]pyrazol-4-yl]-3~{H}-quinolin-4-one | non-polymer | 429.4 | 1 | Chemie (FX2) | |||
| 21 | DA (D) | HEME C | non-polymer | 618.5 | 1 | Chemie (HEC) | |||
| 22 | GA (E) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 1 | Chemie (FES) | |||
| 23 | HA (E) | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 678.9 | 1 | Chemie (PX4) | |||
| 24 | QA, RA, SA, TA, UA... (A, B, C, D, E...) | water | water | 18.0 | 30 | Chemie (HOH) |
Sequence modifications
A: 2 - 445 (UniProt: P31800)
B: 22 - 413 (UniProt: P23004)
F: 11 - 109 (UniProt: P00129)
| PDB | External Database | Details |
|---|---|---|
| - | Thr 256 | deletion |
| - | Tyr 257 | deletion |
| - | Asp 258 | deletion |
| - | Glu 259 | deletion |
| - | Asp 260 | deletion |
| - | Ala 261 | deletion |
| PDB | External Database | Details |
|---|---|---|
| - | Gly 243 | deletion |
| - | Leu 244 | deletion |
| - | Gly 245 | deletion |
| - | Leu 246 | deletion |
| - | Ser 247 | deletion |
| PDB | External Database | Details |
|---|---|---|
| Asp 56 | Asn 57 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 223993.8 | |
| Non-Polymers* | Number of molecules | 32 |
| Total formula weight | 14536.3 | |
| All* | Total formula weight | 238530.0 |
