6HAW
Crystal structure of bovine cytochrome bc1 in complex with 2-pyrazolyl quinolone inhibitor WDH2G7
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005739 | cellular_component | mitochondrion |
A | 0005743 | cellular_component | mitochondrial inner membrane |
A | 0046872 | molecular_function | metal ion binding |
A | 0070469 | cellular_component | respirasome |
B | 0004222 | molecular_function | metalloendopeptidase activity |
B | 0005739 | cellular_component | mitochondrion |
B | 0005743 | cellular_component | mitochondrial inner membrane |
B | 0006508 | biological_process | proteolysis |
B | 0046872 | molecular_function | metal ion binding |
B | 0070469 | cellular_component | respirasome |
C | 0005739 | cellular_component | mitochondrion |
C | 0005743 | cellular_component | mitochondrial inner membrane |
C | 0005750 | cellular_component | mitochondrial respiratory chain complex III |
C | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
C | 0008121 | molecular_function | ubiquinol-cytochrome-c reductase activity |
C | 0009055 | molecular_function | electron transfer activity |
C | 0016020 | cellular_component | membrane |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0020037 | molecular_function | heme binding |
C | 0022904 | biological_process | respiratory electron transport chain |
C | 0031966 | cellular_component | mitochondrial membrane |
C | 0045275 | cellular_component | respiratory chain complex III |
C | 0046872 | molecular_function | metal ion binding |
C | 0048039 | molecular_function | ubiquinone binding |
C | 0070469 | cellular_component | respirasome |
C | 1902600 | biological_process | proton transmembrane transport |
D | 0009055 | molecular_function | electron transfer activity |
D | 0020037 | molecular_function | heme binding |
E | 0008121 | molecular_function | ubiquinol-cytochrome-c reductase activity |
E | 0016020 | cellular_component | membrane |
E | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
F | 0005750 | cellular_component | mitochondrial respiratory chain complex III |
F | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
G | 0005739 | cellular_component | mitochondrion |
G | 0005743 | cellular_component | mitochondrial inner membrane |
G | 0005750 | cellular_component | mitochondrial respiratory chain complex III |
G | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
G | 0070469 | cellular_component | respirasome |
H | 0005750 | cellular_component | mitochondrial respiratory chain complex III |
H | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
I | 0008121 | molecular_function | ubiquinol-cytochrome-c reductase activity |
J | 0005739 | cellular_component | mitochondrion |
J | 0005743 | cellular_component | mitochondrial inner membrane |
J | 0005750 | cellular_component | mitochondrial respiratory chain complex III |
J | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
J | 0070469 | cellular_component | respirasome |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | binding site for residue 6PE A 501 |
Chain | Residue |
A | SER439 |
A | PHE442 |
A | CDL506 |
C | HIS221 |
D | MET222 |
D | LYS226 |
E | PX4202 |
site_id | AC2 |
Number of Residues | 1 |
Details | binding site for residue PGE A 502 |
Chain | Residue |
A | ARG388 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue PO4 A 503 |
Chain | Residue |
A | GLY285 |
A | GLY287 |
A | TYR284 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue PO4 A 504 |
Chain | Residue |
A | ASP332 |
A | MET335 |
A | PHE336 |
A | GLN339 |
A | ARG436 |
site_id | AC5 |
Number of Residues | 7 |
Details | binding site for residue PO4 A 505 |
Chain | Residue |
A | ASP332 |
A | GLN430 |
A | LEU431 |
A | PRO432 |
A | ASP433 |
C | PRO219 |
G | PHE4 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue CDL A 506 |
Chain | Residue |
A | LEU444 |
A | ARG445 |
A | 6PE501 |
C | ARG5 |
C | ILE19 |
site_id | AC7 |
Number of Residues | 3 |
Details | binding site for residue PO4 B 501 |
Chain | Residue |
B | ARG145 |
B | ILE183 |
B | GLY184 |
site_id | AC8 |
Number of Residues | 2 |
Details | binding site for residue PG4 B 502 |
Chain | Residue |
B | GLU381 |
I | ARG62 |
site_id | AC9 |
Number of Residues | 5 |
Details | binding site for residue PX6 B 503 |
Chain | Residue |
B | LYS361 |
B | ASP403 |
B | ALA404 |
B | VAL405 |
B | ALA406 |
site_id | AD1 |
Number of Residues | 12 |
Details | binding site for residue HEM C 401 |
Chain | Residue |
C | GLN44 |
C | GLY48 |
C | LEU49 |
C | LEU51 |
C | ARG80 |
C | HIS83 |
C | THR126 |
C | GLY130 |
C | PRO134 |
C | HIS182 |
C | PHE183 |
C | PRO186 |
site_id | AD2 |
Number of Residues | 15 |
Details | binding site for residue HEM C 402 |
Chain | Residue |
C | TRP31 |
C | GLY34 |
C | LEU37 |
C | HIS97 |
C | ARG100 |
C | SER106 |
C | TRP113 |
C | GLY116 |
C | HIS196 |
C | LEU200 |
C | SER205 |
C | ASN206 |
C | FX2406 |
C | HOH501 |
C | HOH503 |
site_id | AD3 |
Number of Residues | 4 |
Details | binding site for residue LMT C 403 |
Chain | Residue |
C | HIS345 |
C | THR349 |
C | GLN352 |
G | GLU65 |
site_id | AD4 |
Number of Residues | 9 |
Details | binding site for residue CDL C 404 |
Chain | Residue |
C | SER28 |
C | SER29 |
C | TRP30 |
C | PEE405 |
D | CDL503 |
F | GLN72 |
G | VAL37 |
G | ARG40 |
G | THR41 |
site_id | AD5 |
Number of Residues | 11 |
Details | binding site for residue PEE C 405 |
Chain | Residue |
C | TRP30 |
C | TYR95 |
C | TYR103 |
C | TYR104 |
C | MET316 |
C | PHE325 |
C | TRP326 |
C | LEU332 |
C | CDL404 |
G | CYS44 |
G | VAL48 |
site_id | AD6 |
Number of Residues | 8 |
Details | binding site for residue FX2 C 406 |
Chain | Residue |
C | ALA17 |
C | LEU21 |
C | TRP31 |
C | SER35 |
C | LEU197 |
C | HIS201 |
C | PHE220 |
C | HEM402 |
site_id | AD7 |
Number of Residues | 1 |
Details | binding site for residue PGE C 407 |
Chain | Residue |
C | ALA17 |
site_id | AD8 |
Number of Residues | 2 |
Details | binding site for residue PGE C 408 |
Chain | Residue |
C | PHE274 |
C | ILE146 |
site_id | AD9 |
Number of Residues | 1 |
Details | binding site for residue PGE C 409 |
Chain | Residue |
C | PHE128 |
site_id | AE1 |
Number of Residues | 2 |
Details | binding site for residue PX6 C 410 |
Chain | Residue |
C | GLU111 |
C | ASN114 |
site_id | AE2 |
Number of Residues | 13 |
Details | binding site for residue HEC D 501 |
Chain | Residue |
D | CYS37 |
D | CYS40 |
D | HIS41 |
D | ASN105 |
D | ALA108 |
D | PRO111 |
D | ILE116 |
D | ARG120 |
D | TYR126 |
D | PHE153 |
D | GLY159 |
D | MET160 |
D | PRO163 |
site_id | AE3 |
Number of Residues | 3 |
Details | binding site for residue PO4 D 502 |
Chain | Residue |
D | GLY122 |
D | GLU124 |
D | ASP125 |
site_id | AE4 |
Number of Residues | 10 |
Details | binding site for residue CDL D 503 |
Chain | Residue |
C | SER29 |
C | LEU230 |
C | CDL404 |
D | TYR220 |
D | LYS223 |
D | ARG224 |
D | LYS231 |
F | ARG71 |
G | ASN36 |
G | ARG40 |
site_id | AE5 |
Number of Residues | 6 |
Details | binding site for residue FES E 201 |
Chain | Residue |
E | CYS139 |
E | HIS141 |
E | CYS158 |
E | CYS160 |
E | HIS161 |
E | SER163 |
site_id | AE6 |
Number of Residues | 10 |
Details | binding site for residue PX4 E 202 |
Chain | Residue |
A | ASP417 |
A | PHE442 |
A | 6PE501 |
E | TYR37 |
E | THR40 |
E | THR44 |
E | HOH1001 |
J | PHE14 |
J | THR17 |
J | PHE20 |
site_id | AE7 |
Number of Residues | 5 |
Details | binding site for residue PO4 E 203 |
Chain | Residue |
E | ARG15 |
E | PRO16 |
E | GLU17 |
G | ARG24 |
G | PO4101 |
site_id | AE8 |
Number of Residues | 8 |
Details | binding site for residue PEE E 204 |
Chain | Residue |
C | ILE78 |
D | HIS200 |
D | MET204 |
D | LYS207 |
E | TYR49 |
E | ASN53 |
E | GLN57 |
J | ASP36 |
site_id | AE9 |
Number of Residues | 4 |
Details | binding site for residue CDL E 205 |
Chain | Residue |
C | ASN159 |
C | TRP163 |
E | SER60 |
E | SER63 |
site_id | AF1 |
Number of Residues | 2 |
Details | binding site for residue PO4 F 501 |
Chain | Residue |
B | ARG134 |
F | TYR93 |
site_id | AF2 |
Number of Residues | 4 |
Details | binding site for residue PO4 F 502 |
Chain | Residue |
C | VAL215 |
F | GLU39 |
F | TYR55 |
F | ARG58 |
site_id | AF3 |
Number of Residues | 4 |
Details | binding site for residue PO4 G 101 |
Chain | Residue |
E | PO4203 |
G | ARG24 |
G | ALA25 |
G | PHE26 |
site_id | AF4 |
Number of Residues | 4 |
Details | binding site for residue PO4 G 102 |
Chain | Residue |
G | HIS28 |
G | TYR29 |
G | PHE30 |
G | SER31 |
site_id | AF5 |
Number of Residues | 2 |
Details | binding site for residue PO4 G 103 |
Chain | Residue |
G | LEU46 |
G | ARG47 |
Functional Information from PROSITE/UniProt
site_id | PS00143 |
Number of Residues | 24 |
Details | INSULINASE Insulinase family, zinc-binding region signature. GsryensnnlGtSHLLRLAsSlTT |
Chain | Residue | Details |
B | GLY54-THR77 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 25 |
Details | TRANSMEM: Helical => ECO:0000269|PubMed:9651245 |
Chain | Residue | Details |
J | ALA21-ILE46 | |
H | LYS72 | |
F | LYS95 | |
C | PHE178-LEU198 | |
C | ILE226-ALA246 | |
C | LEU288-HIS308 | |
C | LEU320-GLY340 | |
C | TYR347-PRO367 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9CQ69 |
Chain | Residue | Details |
G | LYS32 | |
F | LYS87 |
site_id | SWS_FT_FI3 |
Number of Residues | 133 |
Details | TOPO_DOM: Mitochondrial intermembrane => ECO:0000269|PubMed:9651245 |
Chain | Residue | Details |
E | SER63-GLY196 | |
C | HIS196 |
site_id | SWS_FT_FI4 |
Number of Residues | 5 |
Details | BINDING: BINDING => ECO:0000269|PubMed:9651245, ECO:0007744|PDB:1BE3, ECO:0007744|PDB:1BGY |
Chain | Residue | Details |
E | CYS139 | |
E | HIS141 | |
E | CYS158 | |
E | HIS161 | |
E | SER163 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15312779, ECO:0000269|PubMed:16024040, ECO:0007744|PDB:1PP9, ECO:0007744|PDB:1SQV, ECO:0007744|PDB:2A06, ECO:0007744|PDB:2YBB |
Chain | Residue | Details |
C | HIS201 |