6H2U
Crystal structure of human METTL5-TRMT112 complex, the 18S rRNA m6A1832 methyltransferase at 1.6A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Methyltransferase-like protein 5 | polymer | 215 | 24597.4 | 1 | UniProt (Q9NRN9) Pfam (PF05175) | Homo sapiens (Human) | |
| 2 | B (B) | Multifunctional methyltransferase subunit TRM112-like protein | polymer | 118 | 13439.6 | 1 | UniProt (Q9UI30) Pfam (PF03966) | Homo sapiens (Human) | tRNA methyltransferase 112 homolog |
| 3 | C (A) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) | |||
| 4 | D, E, F, I, J (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 5 | G, H (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 6 | K, L (A, B) | water | water | 18.0 | 320 | Chemie (HOH) |
Sequence modifications
A: 1 - 209 (UniProt: Q9NRN9)
| PDB | External Database | Details |
|---|---|---|
| His 210 | - | expression tag |
| His 211 | - | expression tag |
| His 212 | - | expression tag |
| His 213 | - | expression tag |
| His 214 | - | expression tag |
| His 215 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 38037.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 900.9 | |
| All* | Total formula weight | 38938.0 |
