6H2U
Crystal structure of human METTL5-TRMT112 complex, the 18S rRNA m6A1832 methyltransferase at 1.6A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001650 | cellular_component | fibrillar center |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005829 | cellular_component | cytosol |
| A | 0006364 | biological_process | rRNA processing |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008988 | molecular_function | rRNA (adenine-N6-)-methyltransferase activity |
| A | 0031167 | biological_process | rRNA methylation |
| A | 0032259 | biological_process | methylation |
| A | 0042995 | cellular_component | cell projection |
| A | 0045202 | cellular_component | synapse |
| A | 0045727 | biological_process | positive regulation of translation |
| A | 0048863 | biological_process | stem cell differentiation |
| A | 0098793 | cellular_component | presynapse |
| A | 0098794 | cellular_component | postsynapse |
| A | 1904047 | molecular_function | S-adenosyl-L-methionine binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006364 | biological_process | rRNA processing |
| B | 0008276 | molecular_function | protein methyltransferase activity |
| B | 0018364 | biological_process | peptidyl-glutamine methylation |
| B | 0030488 | biological_process | tRNA methylation |
| B | 0031167 | biological_process | rRNA methylation |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0045815 | biological_process | transcription initiation-coupled chromatin remodeling |
| B | 0046982 | molecular_function | protein heterodimerization activity |
| B | 0048471 | cellular_component | perinuclear region of cytoplasm |
| B | 0070476 | biological_process | rRNA (guanine-N7)-methylation |
| B | 0141106 | molecular_function | tRNA methyltransferase activator activity |
| B | 2000234 | biological_process | positive regulation of rRNA processing |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue SAM A 301 |
| Chain | Residue |
| A | PHE19 |
| A | GLY61 |
| A | CYS62 |
| A | VAL64 |
| A | ASP81 |
| A | ILE82 |
| A | CYS107 |
| A | ASP108 |
| A | VAL109 |
| A | ASN126 |
| A | PRO128 |
| A | LEU26 |
| A | HOH416 |
| A | HOH455 |
| A | HOH521 |
| A | GLU27 |
| A | GLN28 |
| A | TYR29 |
| A | PRO30 |
| A | THR31 |
| A | GLY59 |
| A | CYS60 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 302 |
| Chain | Residue |
| A | VAL54 |
| A | SER119 |
| A | ARG150 |
| A | HOH408 |
| B | LEU8 |
| B | MET45 |
| B | LYS48 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 303 |
| Chain | Residue |
| A | SER113 |
| A | ASN114 |
| A | MET116 |
| A | SER117 |
| A | GLU147 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 304 |
| Chain | Residue |
| A | THR46 |
| A | TYR47 |
| A | HOH402 |
| A | HOH449 |
| A | HOH470 |
| B | HOH334 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 305 |
| Chain | Residue |
| A | THR151 |
| A | ARG206 |
| A | SER208 |
| A | HIS211 |
| A | HOH407 |
| A | HOH421 |
| A | HOH433 |
| A | HOH459 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 306 |
| Chain | Residue |
| A | LYS175 |
| A | HIS210 |
| A | HIS211 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 201 |
| Chain | Residue |
| B | ARG14 |
| B | VAL49 |
| B | GLU50 |
| B | TRP51 |
| B | SER52 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue EDO B 202 |
| Chain | Residue |
| B | HIS12 |
| B | VAL13 |
| B | ARG14 |
| B | SER18 |
| B | ARG19 |
| B | GLY20 |
| B | HOH308 |
| B | HOH355 |
| B | HOH375 |
Functional Information from PROSITE/UniProt
| site_id | PS00092 |
| Number of Residues | 7 |
| Details | N6_MTASE N-6 Adenine-specific DNA methylases signature. VIMNPPF |
| Chain | Residue | Details |
| A | VAL123-PHE129 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31328227, ECO:0007744|PDB:6H2U, ECO:0007744|PDB:6H2V |
| Chain | Residue | Details |
| A | ASP81 | |
| A | ASP108 | |
| A | GLN28 | |
| A | THR31 | |
| A | GLY59 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31328227, ECO:0007744|PDB:6H2U |
| Chain | Residue | Details |
| A | CYS62 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31328227, ECO:0007744|PDB:6H2V |
| Chain | Residue | Details |
| A | VAL64 |
