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6GXW

Crystal structure of Schistosoma mansoni HDAC8 complexed with an hydroxamate 4

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(A, B, C, D)
Histone deacetylasepolymer44750583.04UniProt (A5H660)
Pfam (PF00850)
Schistosoma mansoni (Blood fluke)
2E, L, Q, V
(A, B, C, D)
ZINC IONnon-polymer65.44Chemie (ZN)
3F, G, M, N, R...
(A, B, C, D)
POTASSIUM IONnon-polymer39.18Chemie (K)
4H, O, T, Y
(A, B, C, D)
(~{E})-3-[2-[[2,6-bis(chloranyl)phenyl]methoxy]phenyl]-~{N}-oxidanyl-prop-2-enamidenon-polymer338.24Chemie (FGN)
5I, J, P
(A, C)
DIMETHYLFORMAMIDEnon-polymer73.13Chemie (DMF)
6K, U, Z
(A, C, D)
GLYCEROLnon-polymer92.13Chemie (GOL)
7AA, BA, CA, DA
(A, B, C, D)
waterwater18.0761Chemie (HOH)
Sequence modifications
A, B, C, D: 1 - 440 (UniProt: A5H660)
PDBExternal DatabaseDetails
His 0-expression tag
Gly 441-expression tag
Ser 442-expression tag
Leu 443-expression tag
Val 444-expression tag
Pro 445-expression tag
Arg 446-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight202332.1
Non-Polymers*Number of molecules22
Total formula weight2422.7
All*Total formula weight204754.8
*Water molecules are not included.

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PDB entries from 2025-03-12

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